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Biophysical Society 59
th
Annual Meeting, Baltimore, Maryland
1744-P
lat
11:45
am
STRUCTURAL ORIGIN OF LANDSCAPE ROUGHNESS IN
PROTEIN FOLDING FROM SINGLE-MOLECULE FRET AND
ALL-ATOM MOLECULAR DYNAMICS SIMULATIONS.
Hoi Sung Chung
, Stefano Piana-Agostinetti, David E. Shaw, William A.
Eaton
1745-P
lat
12:00
pm
RESOLVING COOPERATIVE INTERACTIONS IN PROTEIN
FOLDING.
Jacob D. Marold
, Thuy P. Dao, Tural Aksel, Doug Barrick
1746-P
lat
12:15
pm
MAPPING THE MECHANISM OF FAST PROTEIN FOLDING
WITH MULTIPLE PROBES.
Taras V. Pogorelov
, Maxim B. Prigozhin,
Shu-Han Chao, Martin Gruebele
1747-P
lat
12:30
pm
PHOTOBLEACHING AND STABILITY OF RED FLUORESCENT
PROTEINS.
Mengyang Xu
, Deepu K. George, Ralph Jimenez, Andrea
G. Markelz
10:45
am
–12:45
pm
, B
allroom
III
Platform
Voltage-gated K Channels II
Co-Chairs
Jianmin Cui, Washington University in St. Louis
Kelly Aromolaran, Albert Einstein College of Medicine
1748-P
lat
10:45
am
EMERGING ROLE FOR KCNQ1 IN ISCHEMIA-INDUCED
NEURONAL DEATH.
Kelly A. Aromolaran
, Jee-Yeon Hwang, Thomas
V. McDonald, R.Suzanne Zukin
1749-P
lat
11:00
am
SPECTROSCOPIC AND BIOCHEMICAL STUDIES OF TRIP8B
REGULATION OF HCN CHANNELS.
John R. Bankston
, Hannah
A. DeBerg, Joel C. Rosenbaum, Peter S. Brzovic, Stefan Stoll, William N.
Zagotta
1750-P
lat
11:15
am
EPILEPSY RELATED SLACK CHANNEL MUTANTS LEAD
TO CHANNEL OVER-ACTIVITY BY TWO DIFFERENT
MECHANISMS. Qiong-Yao Tang, Fei-Fei Zhang, Jie Xu, Ran Wang,
Jian Chen,
Zhe Zhang
1751-P
lat
11:30
am
QUANTUM CALCULATIONS SHOW A WATER COLUMN IN A
POTASSIUM ION CHANNEL PORE, AND ITS ROLE IN GATING
AND CONDUCTION. Alisher M. Kariev,
Michael E. Green
1752-P
lat
11:45
am
PIP2 AND SURFACE EXPRESSION UNDERLIE APO-
CALMODULIN DEPENDENT KV7.2/KCNQ2 CURRENT
POTENTIATION.
Carolina Gomis-Perez
, Maria Virginia Soldovieri,
Araitz Alberdi, Paolo Ambrosino, Michela Di Maria, Alessandro Alaimo,
Ganeko Bernardo-Seisdedos, Covadonga Malo, Pilar Areso, Maurizio
Taglialatela, Alvaro Villarroel
1753-P
lat
12:00
pm
THE MECHANISM OF KCNE1 MODULATION OF KCNQ1
CHANNELS. Mark A. Zaydman, Marina Kasimova, Kelli Delaloye,
Jingyi Shi, Hongwu Liang, Zachary Beller, Mounir Tarek,
Jianmin Cui
1754-P
lat
12:15
pm
international
travel awardee
DISRUPTION OF ASSEMBLY/CALMODULIN-BINDING
COUPLING AND CALMODULIN-DEPENDENT POTENTIATION
OF KV7.2 CHANNELS BY A EPILEPTOGENIC HELIX D
MUTATION.
Araitz Alberdi
, Ganeko Bernardo-Seisdedos, Carolina
Gomis-Perez, Alessandro Alaimo, Covadonga Malo, Elisabeth Butz,
Christian Wahl-Schott, Pilar Areso, Alvaro Villarroel
1755-P
lat
12:30
pm
STATIN INHIBITS IKS INTERNALIZATION IN RESPONSE
TO PROLONGED STRESS STIMULUS.
Xiaorong Xu Parks
, Elsa
Ronzier, Rachael E. Abraham, Jin O-Uchi, Coeli M. Lopes
10:45
am
–12:45
pm
, B
allroom
IV
Platform
Membrane Receptors and Signal
Transduction
Co-Chairs
Kalina Hristova, Johns Hopkins University
Nils Berglund, Bioinformatics Institute, Singapore
1756-P
lat
10:45
am
CONFRONTATIONAL DYNAMICS OF A GPCR REVEALED BY
SINGLE MOLECULE FRET.
Reza Vafabakhsh
, Joshua Levitz, Ehud Y.
Isacoff
1757-P
lat
11:00
am
BIASED AGONISM AT OPIOID RECEPTORS: INSIGHTS FROM
ANALYSIS OF STRUCTURAL INTERACTION FINGERPRINTS.
Davide Provasi
, Paola Bisignano, Marta Filizola
1758-P
lat
11:15
am
CONFORMATIONAL DYNAMICS OF A G PROTEIN-COUPLED
RECEPTOR AT THE SINGLE-MOLECULE LEVEL.
Rajan Lamichhane
, Jeffrey J. Liu, Raymond C. Stevens, David P. Millar
1759-P
lat
11:30
am
ENTRY FROM THE LIPID BILAYER: A NOVEL PATHWAY FOR
INHIBITION OF A PEPTIDE G-PROTEIN COUPLED RECEPTOR
BY A LIPOPHILIC SMALL MOLECULE.
Michael P. Bokoch
, Hyunil
I. Jo, James R. Valcourt, Yoga Srinivasan, Kazuma Yasuhara, Albert
C. Pan, Ron O. Dror, David E. Shaw, William F. DeGrado, Shaun R.
Coughlin
1760-P
lat
11:45
am
SINGLE MOLECULE IMAGING OF M
2
MUSCARINIC
RECEPTORS IN LIVE HEART EXPLANTS.
Gregory I. Mashanov
,
Tatiana A. Nenasheva, Ross A. Breckenridge, Nigel J.M. Birdsall, Justin E.
Molloy
1761-P
lat
12:00
pm
THE STRUCTURAL BASIS FOR LIPID A RECOGNITION IN THE
CD14 INNATE IMMUNE CO-RECEPTOR.
Nils A. Berglund
, Daniel
A. Holdbrook, Syma Khalid, Peter J. Bond
1762-P
lat
12:15
pm
INSIDE-OUT SIGNALING OF ONCOGENIC EGFR MUTANTS
PROMOTES LIGAND-INDEPENDENT DIMERIZATION.
Christopher C. Valley
, Donna J. Arndt-Jovin, Thomas M. Jovin, Mara
P. Steinkamp, Alexey I. Chizhik, Narain Karedla, William S. Hlavacek,
Bridget S. Wilson, Keith A. Lidke, Diane S. Lidke
1763-P
lat
12:30
pm
MECHANISMS OF AUTOINHIBITION AND DIMERIZATION
OF THE EGF RECEPTOR FAMILY.
Patrick Byrne
, Kalina Hristova,
Daniel Leahy