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Biophysical Society 59
th
Annual Meeting, Baltimore, Maryland
924-P
lat
10:00
am
USING LONG-TIMESCALE MOLECULAR DYNAMICS
SIMULATIONS TO BENCHMARK ENHANCED SAMPLING
METHODS.
Albert C. Pan
, Thomas M. Weinreich, Stefano Piana,
David E. Shaw
8:15
am
–10:15
am
, R
oom
314/315
Platform
Protein Dynamics and Allostery I
Co-Chairs
Ian Thorpe, University of Maryland, Baltimore
Lukas Stelzl, University of Oxford, United Kingdom
925-P
lat
8:15
am
ALLOSTERIC COMMUNICATION WITHIN THE CYTOPLASMIC
REGION OF THE HISTIDINE KINASE CPXA, REVEALED BY
MOLECULAR DYNAMICS SIMULATIONS OF THE WILD-TYPE
AND M228V PROTEINS.
Marlet Martinez
, Nathalie Duclert, Jean-
Michel Betton, Pedro M. Alzari, Michael Nilges, Thérèse E. Malliavin
926-P
lat
8:30
am
STUDYING THE CONFORMATIONAL EQUILIBRIUM OF THE
N-TERMINAL DOMAIN OF DSBD BY NMR AND COMPUTER
SIMULATION.
Lukas S. Stelzl
, Despoina A.I. Mavridou, Stuart J.
Ferguson, Andrew J. Baldwin, Mark S.P. Sansom, Christina Redfield
927-P
lat
8:45
am
FUNCTIONAL MECHANISM OF THE PHOTOACTIVE YELLOW
PROTEIN: A TRANSIENT ABSORPTION SPECTROSCOPY
PERSPECTIVE.
Chandra P. Joshi
, Harald Otto, Maarten P. Heyn
928-P
lat
9:00
am
DUAL ALLOSTERIC INHIBITORS EXHIBIT ANTAGONISTIC
EFFECTS IN THE HEPATITIS C VIRUS POLYMERASE. Jodian A.
Brown,
Ian F. Thorpe
929-P
lat
9:15
am
MICROSECOND MOTION MODULATES UBIQUITIN BINDING
THROUGH AN ALLOSTERIC BACKBONE/SIDE CHAIN
NETWORK.
Colin A. Smith
, David Ban, Karin Giller, Stefan Becker,
Christian Griesinger, Donghan Lee, Bert L. de Groot
930-P
lat
9:30
am
ALLOSTERY IN PDZ3: USING UNNATURAL AMINO ACIDS AS
SITE-SPECIFIC REPORTERS IN IR SPECTROSCOPY TO PROBE
ALLOSTERIC PATHWAYS.
Katharina B. Eberl
, Henrike M. Müller-
Werkmeister, Martin Essig, Jens Bredenbeck
931-P
lat
9:45
am
ALLOSTERIC COMMUNICATION IN RND1 AND RAC1
ASSOCIATION WITH THE PLEXIN-B1 RHOGTPASE BINDING
DOMAIN REVEALED BY HYDROGEN EXCHANGE MASS
SPECTROSCOPY AND BY SOLUTION NMR.
Shufen Cao
, Matthias
Buck
932-P
lat
10:00
am
CONFORMATIONAL TRANSITIONS IN SWITCH REGIONS
OF THE RAS-LIKE GTPASE RAB1B STUDIED BY FREE ENERGY
SIMULATIONS.
Manuel Patrick Luitz
, Rainer Bomblies, Martin
Zacharias, Evelyn Bender, Aymelt Itzen
8:15
am
–10:15
am
, R
oom
316/317
Platform
Micro- and Nanotechnology
Co-Chairs
Aleksandra Radenovic, Ecole Polytech Federal Lausanne, Switzerland
Sergey Bezrukov, NIH/NICHD
933-P
lat
8:15
am
PROBING THE MOTION OF THE INTRINSICALLY
DISORDERED NEURONAL PROTEIN ALPHA-SYNUCLEIN
THROUGH THE VDAC PORE USING A SINGLE-MOLECULE
APPROACH.
David P. Hoogerheide
, Philip A. Gurnev, Tatiana K.
Rostovtseva, Sergey M. Bezrukov
934-P
lat
8:30
am
USING NANOPARTICLES TO CONTROL CELLULAR
MEMBRANE POTENTIAL.
Emilie A.K. Warren
, Christine K. Payne
935-P
lat
8:45
am
ELECTRO-WETTING OF A HYDROPHOBIC GATE IN A
BIOMIMETIC NANOPORE.
Jemma L. Trick
, Chen Song, Jayne E.
Wallace, Hagan Bayley, Mark S P Sansom
936-P
lat
9:00
am
DEFORMATION OF MCF-7 CELLS IN MICROPORES WITH
UNDULATING DIAMETER.
Laura M. Innes
, Ashley Fong, Matthew
Pevarnik, Matthew Schiel, Eugenia Toimil-Molares, Luke Theogarajan,
Christopher Hughes, Zuzanna Siwy
937-P
lat
9:15
am
FINGERPRINTING SINGLE LIVING CELLS WITH MOLECULAR
PRECISION.
Kim McKelvey
, Volker Kurz, Tetsuya Tanaka, Gregory
Timp
938-P
lat
9:30
am
MECHANICAL MODULATION OF ENZYME ACTIVITY BY
RATIONALLY DESIGNED DNA TWEEZERS: FROM THE
ENSEMBLE TO THE SINGLE-MOLECULE LEVEL.
Soma Dhakal
,
Minghui Liu, Matthew R. Adendorff, Mark Bathe, Hao Yan, Nils G.
Walter
939-P
lat
9:45
am
REGULATION OF LIPID MEMBRANE TRAFFICKING AND
TRANSMEMBRANE SIGNALING BY GRAPHENE.
Kristina E.
Kitko
, Tu Hong, Roman Lazarenko, Da Ying, Yaqiong Xu, Qi Zhang
940-P
lat
10:00
am
DEVELOPMENT OF A FLUORESCENCE-BASED ASSAY FOR
FUNCTIONAL STUDIES OF TRANSPORTER PROTEINS ON THE
SINGLE MOLECULE LEVEL. Salome Veshaguri, Sune M. Christensen,
Mads P. Møller
, Garima Ghale, Christina Lohr, Andreas L. Christensen,
Marijonas Tutkus, Gerdi Kemmer, Ida L. Jørgensen, Bo H. Justesen,
Patricia Curran, Thomas G. Pomorski, Joseph Mindell, Dimitrios Stamou
8:30
am
–10:00
am
, H
all
C, R
oom
B
Exhibitor Presentation
FEI Company
Advances in Correlative Light and Electron Microscopy
Correlative light and electron microscopy (CLEM) is a powerful approach
that enables combining dynamic information and labelling specificity
from fluorescence microscopy with ultra-structural information at
nanometer resolution from electron microscopy on the same sample. In
recent years technical improvements in fluorescence microscopy have
enhanced z-resolution, enabled imaging with high sensitivity using TIRF