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Biophysical Society 59
th
Annual Meeting, Baltimore, Maryland
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A
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11:45
am
–1:15
pm
, R
oom
327/328/329
Undergraduate Student Pizza “Breakfast”
The Education Committee is hosting this “breakfast” for undergraduate
students. This session provides a valuable networking and social
opportunity for undergraduate student attendees to meet other students
and Committee members, to discuss academic goals and questions, and
to develop a biophysics career path. The Emily M. Gray Awardee will also
give a talk at this event. Limited to the first 100 attendees.
Emily Gray Awardee Speaker
Meyer Jackson, University of Wisconsin-Madison
12:30
pm
–2:00
pm
, H
all
C, R
oom
B
Exhibitor Presentation
Nanion Technologies GmbH
HTS-Compatible Giga-Seal Ion Channel Drug Discovery: Beyond the
Bottleneck and Ready for CiPA
Nanion Technologies is one of the leading providers of automated patch
clamp systems, offering a diverse product portfolio covering a broad
experimental range from single channel recordings to HTS-compatible
ion channel screening from up to 768 cells in parallel. Allowing 20,000
data points per day, the SyncroPatch 384/768PE is unrivalled for high
throughput and high quality recordings. Diverse ion channel targets and
cell types have successfully been tested on the SyncroPatch 384/768PE
including challenging targets such as fast desensitizing ligand ion channels
(P2X3 und GluA2), ion channels requiring intracellular activation (Katp,
TMEM16a) and heavily regulated channels such as TRPA1.
Early cardiac arrhythmic risk assessment is a hot topic these days calling
for new safety screening strategies. Patchliner, a medium-throughput APC
platform, supports automated current clamp recordings, experiments
at physiological temperatures, and a minimal cell usage, making it the
ideal partner for safety testing on stem cell derived cardiomyocytes.
Additionally, the CardioExcyte 96, a unique hybrid system for parallel
impedance-based and MEA-like recordings from intact cardiomyocyte
networks, has proven a versatile tool for safety and toxicity screening
applications serving as an excellent complement to APC. These three
platforms enable you to keep up with the requirements of the CiPA-
initiative for early prediction of potential cardiac arrhythmias.
During this workshop, we will show how to push the boundaries of ion
channel screening projects to achieve HTS-screening standards, and how
to get ready for comprehensive safety screening beyond hERG.
Spaces are limited so reserve yours by sending an email to
info@nanion.de.
Presenters
Niels Fertig, CEO, Nanion Technologies
Andrea Brüggemann, CSO, Nanion Technologies
1:00
pm
–3:00
pm
, H
all
C
Graduate and Postdoc Institution Fair
This fair will introduce students and postdoctoral candidates to colleges
and universities with leading programs in biophysics. Registration is not
needed to participate.
1:00
pm
–3:00
pm
, R
oom
324/325
Grant Writing Workshop
How (Not) to Write Your NIH Grant Proposal
Through mock study sections and discussions, veteran NIH officials
will demonstrate what review panels look for when they read and assess
proposals. They will also answer questions about peer review, avoiding
application pitfalls and responding to review concerns. This session is
sponsored by the Public Affairs Committee and is appropriate for both
experienced principal investigators and those applying for their first grant.
Speakers
Jean Chin, NIGMS, NIH
Catherine Lewis, NIGMS, NIH
James Mack, CSR, NIH
Don Schneider, CSR, NIH
Mary Ann Wu, NIGMS, NIH
1:30
pm
–3:00
pm
, H
all
C, R
oom
A
Exhibitor Presentation
World Precision Instruments
Side-Stepping the Animal Model: Cardiac Work Loops in Human
iPSC-derived Myocytes
Cardiac pressure-volume loops on a complete organ provide the
framework for understanding cardiac mechanics in experimental animal
models, most notably in the context of Frank-Starling mechanisms. With
the development of more sensitive transducers, this work has been applied
to single cardiac cells, using freshly isolated cells from an animal model.
With the advent of iPSC-derived myocytes, a whole new range of cell
types is now available to the investigator. We introduce a novel mounting
application for overcoming the technical difficulties in instrumenting
these cells for force measurements. With this technology, it is now possible
to conduct experiments on human stem cell-derived myocytes.
We will show preliminary results, the tools required for these types of
experiments, mounting methods, and a novel method for direct force
measurements on human iPSC-derived myocytes. In addition, two
different methods for real-time determination of length changes in isolated
iPSC-derived myocytes will be presented. The results are preliminary,
however indicate the possibility for not only a reduction in the use of
the animal models in cardiac research, but also the direct investigation of
human cardiovascular disease.
1:30
pm
–3:00
pm
, R
oom
330
Biophysics 101:
Super-Resolution Microscopy
Eric Betzig, Stefan W. Hell and William E. Moerner were awarded the
Nobel Prize in Chemistry 2014 for their great achievements in developing
super-resolution/single-molecule microscopy. This revolutionary progress
in optical microscopy enables us to have an unprecedented power peering
into the nanoworld in live organisms. This year’s “Biophysics 101” session
will include two lectures on this topic, outlining the practice of super-
resolution/single-molecule microscopy for not-yet-experts, and describing
some of its uses and rewards. The session is part of a continuing series of
symposia initiated by the Education Committee to educate the Society
membership about fundamentals of various biophysical techniques with
which they may not be familiar but might want to use.
Speakers
Keith Lidke, University of New Mexico
Weidong Yang, Temple University