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66

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

10:45

am

–12:45

pm

, B

allroom

I

Symposium

Epigenetics

Chair

Lene Oddershede, University of Copenhagen, Denmark

941-S

ymp

10:45

am

COST AND PRECISION IN SMALL GENE REGULATORY

NETWORKS.

Aleksandra Walczak

942-S

ymp

11:15

am

METAPHASE CHROMATIN PLATES EXPLAIN THE

STRUCTURE AND PHYSICAL PROPERTIES OF CONDENSED

CHROMOSOMES.

Joan-Ramon Daban

943-S

ymp

11:45

am

COOPERATIVITY AND SUPERCOILING MODULATE

FUNCTIONS OF HUMAN O6-ALKYLGUANINE DNA

ALKYLTRANSFERASE.

Michael G. Fried

, Manana Melikishvili, Ingrid

Tessmer

944-S

ymp

12:15

pm

DNA SUPERCOILING ENHANCES COOPERATIVITY AND

EFFICIENCY OF AN EPIGENETIC SWITCH. Kamilla Nørregaard,

Magnus Andersson, Peter E. Nielsen, Stanley Brown,

Lene B. Oddershede

10:45

am

–12:45

pm

, B

allroom

II

Symposium

Mechanisms of Actin Filament Nucleation

and Mechanotransduction

Chair

Roberto Dominguez, University of Pennsylvania

945-S

ymp

10:45

am

MECHANOSENSITIVITY OF FORMIN-ACTIN INTERACTIONS.

Guillaume Romet-Lemonne

946-S

ymp

11:15

am

WISH/DIP/SPIN90 PROTEINS ACTIVATE ARP2/3 COMPLEX TO

CREATE LINEAR ACTIN FILAMENTS THAT SEED ASSEMBLY OF

BRANCHED ACTIN NETWORKS.

Brad Nolen

947-S

ymp

11:45

am

TWO TYPES OF ACTIN NUCLEATORS, THREE WAYS TO MAKE

ACTIN FILAMENTS?

Margot Quinlan

948-S

ymp

12:15

pm

MOLECULAR MECHANISM OF ACTIN FILAMENT

NUCLEATION BY LEIOMODIN (LMOD). Malgorzata Boczkowska,

Grzegorz Rebowski,

Roberto Dominguez

10:45

am

–12:45

pm

, B

allroom

III

Symposium

Molecular Basis for Mitochondrial Signaling

Chair

Tatiana Rostovtseva, NIH

949-S

ymp

10:45

am

SYSTEMS APPROACHES TO MITOCHONDRIAL CALCIUM

SIGNALING. Jennifer Wettmarshausen, Yiming Cheng,

Fabiana Perocchi

950-S

ymp

11:15

am

THE MITOCHONDRIAL CALCIUM UNIPORTER: MOLECULAR

COMPOSITION AND PHYSIOLOGICAL ROLE.

Rosario Rizzuto

951-S

ymp

11:45

am

MOLECULAR MECHANISMS OF MITOCHONDRIAL CA

2+

UPTAKE: ROLE OF MICU1 AND ITS PARALOGS.

György Hajnóczky

952-S

ymp

12:15

pm

HIGH-AFFINITY INTERACTION WITH VDAC LINKS

CYTOSOLIC PROTEINS TO MITOCHONDRIAL REGULATION

IN HEALTH, CANCER, AND NEURODEGENERATION.

Tatiana K. Rostovtseva

, Philip A. Gurnev, David P. Hoogerheide,

Eduardo N. Maldonado, John J. Lemasters, Olga Protchenko, Jennifer C.

Lee, Sergey M. Bezrukov

10:45

am

–12:45

pm

, B

allroom

IV

Platform

Electron Microscopy and Solution Scattering

Co-Chairs

Doreen Matthies, NIH

Daisbube Kihare, Purdue University

953-P

lat

10:45

am

GFP FOR EM: SITE-SPECIFIC LABELING OF PROTEINS FOR

ELECTRON MICROSCOPY.

Corey M. Dambacher

, Gabriel C.

Lander

954-P

lat

11:00

am

FAST SHAPE-BASED GLOBAL AND LOCAL ELECTRON

DENSITY MAP SEARCH. Juan Esquivel-Rodriguez, Xusi Han, Charles

Christoffer, Xuejiao Kang, Lyman Monroe,

Daisuke Kihara

955-P

lat

11:15

am

CYCLOPHILIN A STABILIZES THE MATURE HIV-1 CAPSID

THROUGH A NOVEL NON-CANONICAL BINDING SITE.

Peijun Zhang

, Chuang Liu, Juan R. Perilla, In-Ja Byeon, Jiying Ning,

Jinwoo Ahn, Chris Aiken, Angela M. Gronenborn, Tatyana Polenova,

Klaus Schulten

956-P

lat

11:30

am

RESIDUE SPECIFIC RADIATION DAMAGE OF PROTEIN

STRUCTURES USING HIGH-RESOLUTION CRYO-ELECTRON

MICROSCOPY.

Doreen Matthies

, Alberto Bartesaghi, Alan Merk,

Soojay Banerjee, Sriram Subramaniam

957-P

lat

11:45

am

3D ULTRASTRUCTURAL INVESTIGATION OF ENTIRE

PANCREATIC ISLETS OF LANGERHANS BY SERIAL BLOCK

FACE SCANNING ELECTRON MICROSCOPY. Gina N. Calco, Jake

D. Hoyne,

Bryan C. Kuo

, Maria A. Aronova, Guofeng Zhang, Andre

Shomorony, Charlotte R. Pfeifer, Tao Cai, Huanyu Xu, Abner L. Notkins,

Richard D. Leapman

958-P

lat

12:00

pm

SUPERRESOLUTION FLUORESCENCE MICROSCOPY WITHIN

A SCANNING ELECTRON MICROSCOPE.

Craig L. Hetherington

,

Connor G. Bischak, Claire E. Stachelrodt, Jake T. Precht, Zhe Wang,

Darrell G. Schlom, Naomi S. Ginsberg

959-P

lat

12:15

pm

CCP-SAS - NOVEL APPROACHES FOR THE ATOMISTIC

MODELLING OF SMALL ANGLE SCATTERING DATA IN

BIOLOGY.

David W. Wright

, Ruodan Nan, Gar-Kay Hui, Joseph E.

Curtis, Emre H. Brookes, Stephen J. Perkins