119 / 134
A
A
A
Q Fever Pneumonia: Guinea pig model
PBS
Cont
rol
7
da
ys
p.i.
28
day
B
1
1
2
3
B
2
B
3
C
1
C
3
C
2
s
p.i.
28 days
p.i.,
vaccina
ted
D
1
D
2
D
3
C. burnetii
infection leads to pneumonia at high doses.
7d pi – panleukocytic bronchointerstitial pneumonia
28d pi – lymphohistiocytic interstitial pneumonia
Formalin inactivated Whole Cell
Vaccine (WCV)
Q-vax
®
:
Effective Q fever vaccine
licensed for used in Australia
Long-lived, single dose
Not FDA approved: IND material
Serious side effects in previously
sensitized individuals (local and
systemic)
Requires pre-screening: Skin test and
phase I/phase II serology
Next generation vaccines under
development