AOAC-03 Preliminary Program

LEADING THE INDUSTRY in Food Science and Safety Preliminary Program

130th Annual Meeting & Exposition September 18 – 21, 2016 Dallas, Texas

130th Annual Meeting & Exposition September

18–21, 2016 Dallas, Texas

AOAC INTERNATIONAL is a non-profit scientific association dedicated to the development and validation of analytical methods, improvement of quality assurance procedures in laboratories, and the professional development of scientists. Since its founding in 1884, AOAC has evolved from a group of scientists within the U.S. federal government into an independent association of over 3,000 analytical chemists, microbiologists, and other scientists engaged in a wide range of positions in industry, government, and academic laboratories around the world.

Table of Contents 4 Acknowledgments 5 Welcome from the President of AOAC INTERNATIONAL 6 Schedule at a Glance 9 H.W. Wiley Award Address 11 Keynote Address 12 Stakeholder Panels 13 Exposition & Exhibitor/Partner Presentation Information

14 Scientific Sessions 26 Poster Presentations 36 Special Events 38 Meeting & Travel Information 39 Registration Information

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September 18–21, 2016

Sheraton Hotel, Dallas, Texas

Why Attend the 130th AOAC Annual Meeting? The greatest minds, talent, innovations, and solutions for methods based science can be found at the AOAC INTERNATIONAL Annual Meeting & Exposition. This once a year event is unlike any other you will attend within the industry. Educate. Network. Collaborate. The AOAC Annual Meeting & Exposition is the epitome of those three words. AOAC and the standards-based scientific community have evolved. The future of AOAC is to provide solutions and to take on the global goal within our community to advance science by establishing standards and approving more methods FASTER… so that our member companies, our individual scientist members, and all others associated with the methods process can experience the reality of their work. The AOAC Annual Meeting & Exposition is the one source where the industry gathers to learn and collaborate on the past, present, and future of science and the business of analytic scientific evaluation.

HIGHLIGHTS: • Nearly 900 attendees • Over 64 exhibiting companies • 15 Exhibitor Presentations • Over 250 posters • Open access to all member community meetings • 27 scientific sessions ranging in a variety of topics in food safety and security

• Sunday Training Courses included in registration fees • Networking receptions on Sunday, Monday, and Wednesday • Over 30% of attendees are international

For 2016, the AOAC Annual Meeting & Exposition‘s education is the most relevant and impactful lineup of scientific sessions and poster presentations we have offered to date. We are very proud of our exhibitor list and excited for you to meet with them and learn about their products and services and to collaborate with them to stay on top of the most cutting-edge trends and innovations within our industry. Whether you are a long time AOAC Annual Meeting attendee or an industry professional curious and interested what AOAC is all about and wondering where a relationship with the organization might fit into your professional agenda, we invite you to attend and experience the 2016 Annual Meeting & Exposition. We are confident your attendance will be considered time well spent. The best minds, talent, innovations, and solutions sharing a common goal…to approve, establish global standards, and advance science. Register today to share in the experience!

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Acknowledgments 2015-16 AOAC TECHNICAL PROGRAMMING COUNCIL AOAC wishes to express its sincere thanks to the members of the Technical Programming Council for their efforts in developing and coordinating the technical program for this year’s Annual Meeting. Alexander J. Krynitsky, Chair U.S. Food and Drug Carmen Diaz-Amigo Independent Consultant Grézieu-La-Varenne, France Jon Wong U.S. Food and Drug Administration College Park, MD, USA

Administration (Retired) College Park, MD, USA

Ana Gago-Martinez Universidad de Vigo Vigo, Spain

Donna Zink AIM Research Enterprises Carthage, MO, USA Shauna Roman, Ex-Officio Member Reckitt Benckiser Salt Lake City, UT, USA

Michael A. McLaughlin, Vice Chair U.S. Food and Drug Administration Rockville, MD, USA

Jane Weitzel Independent Consultant Winnipeg, Manitoba, Canada

Patrick Bird Q Laboratories Cincinnati, OH, USA

John Szpylka Silliker Laboratories Chicago, IL, USA

Amit Chandra AMWAY Ada, MI, USA

2015-16 AOAC INTERNATIONAL BOARD OF DIRECTORS Norma Hill, President U.S. Treasury (Retired) Concord, CA, USA DeAnn Benesh, Director 3M Food Safety Saint Paul, MN, USA Brad Goskowicz, Director Microbiologics, Inc. Saint Cloud, MN, USA

Lei Bao, Director ShanDong Entry-Exit Inspection

Erik J. M. Konings, Past President Nestlé Research Center Lausanne, Switzerland Ron L. Johnson, President - Elect bioMérieux, Inc. Hazelwood, MO, USA Darryl M. Sullivan, Secretary Covance Laboratories Madison, WI, USA Jonathan W. DeVries, Treasurer Medallion Laboratories/ General Mills (Retired) Minneapolis, MN, USA

Stephen A. Wise, Director at Large NIH Office of Dietary Supplements Bethesda, MD, USA Daniel S. Fabricant, Director at Large Natural Products Association Washington, DC, USA

and Quarantine Bureau Qing Dao City, Peoples Republic of China

Samuel Benrejeb Godefroy, Director University Laval Quebec City, Canada

E. James Bradford, Executive Director AOAC INTERNATIONAL Rockville, MD, USA

Clay Detlefson, Director National Milk Producers Federation Arlington, VA, USA

David W. K. Acheson, Director The Acheson Group Washington, DC, USA

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September 18–21, 2016

Sheraton Hotel, Dallas, Texas

Welcome

Welcome from the President of AOAC INTERNATIONAL On behalf of the entire Board of Directors and staff of AOAC INTERNATIONAL, I am pleased to welcome you to the 130th Annual Meeting and Exposition in Dallas, Texas. AOAC is a world class Standards Development Organization. I urge you to attend at least one of the stakeholder panels, working groups or expert review panels and discover the heart of the new nimble, active, alive AOAC. AOAC is honored to announce this year’s keynote speaker, Dr. Gregory Noonan, Director of the Division of Bioanalytical Chemistry in the Center for Food Safety and

Applied Nutrition of the U.S. Food and Drug Administration. His division focuses on the development and validation of methods in a broad range of areas including, toxic and nutrient elements, mycotoxins, pesticides, contaminants in dietary supplements and cosmetics, and the analysis of fats and oils. Dr. Noonan has been a member of the U.S. delegation to the Codex Committee on Methods of Analysis and Sampling (CCMAS) and is currently the U.S. Delegate to CCMAS, as well as the Chair of the Endorsement Working Group. Since joining the delegation in 2007 he has worked in conjunction with other delegations and stakeholders on a number of Codex Guidelines, including: “Guidelines for Settling Disputes on Analytical (Test) Results” (CAC GL70-2009), and “Guidelines on Performance Criteria and Validation of Methods for Detection, Identification and Quantification of Specific DNA Sequences and Specific Proteins in Foods” (CAC CL 74/2010). As the U.S. Delegate Dr. Noonan has helped advance the “Principles for the use of sampling and testing in international trade” (CAC/GL 83-2013) and is currently working on changes to the Procedural Manual to address criteria approaches for methods that require a “sum of components” and not a single analyte measurement to assess compliance with a specifications. Dr. Jana Hajšlová, head of the Department of Food Analysis and Nutrition at the University of Chemistry and Technology, Prague, Czech Republic, is the 2016 AOAC Harvey W. Wiley recipient. She is being recognized for her significant contributions to academia and research concerned with the development and implementation of advanced analytical strategies applicable in food quality, authenticity and safety control. The quality of the technical program at AOAC’s Annual Meeting is renowned and this year is no exception. After attending this program you will agree that AOAC sets the bar for technical symposia. Take a moment to explore the poster sessions. I often find a young researcher there who has a unique take on the analytical problems we pursue. Especially, I want to thank the meeting sponsors, partners and exhibitors. The Exhibit Hall will feature a highly impressive display of the latest technological developments and services to help you with your analytical needs. I invite you to take full advantage of all outstanding opportunities that the AOAC Annual Meeting has to offer. Learn about new research, share your findings, hear from a variety of experts in your field, network with colleagues, and much more. Please join me at the Exhibit Hall Grand Opening and President’s Welcome Reception on Sunday evening to kick off what is sure to be another outstanding AOAC Annual Meeting and Exposition.

Norma Hill

President, AOAC INTERNATIONAL

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Schedule at a Glance

SATURDAY, SEPTEMBER 17, 2016 9:00 am – 5:00 pm Registration Open

1:30 pm – 3:00 pm

Symposium: Laboratory Accreditation – Progress towards the Nation’s Integrated Food/Feed Safety System Symposium: Culture Independent Detection Methods—Scope and Validation Strategies for Routine Application in Food Laboratories Expert Review Panel—SPSFAM Allergens Exhibitor Presentation: Covance Laboratories Workshop: Technical Committee for Juice and Juice Products (TCJJP)—The Basics of Fruit Juice Quality Assessment Symposium: Botanical Dietary Supplement Ingredient Identity Authentication—Determining Appropriate Reference Materials for Botanicals and their Extracts Symposium: Synthetic Color Additives – Developing Modern Analytical Methods and Reference Materials Agricultural Materials Community Meeting Research Institute Expert Review Panel—Fertilizer Refreshment Break

1:30 pm – 3:00 pm

SUNDAY, SEPTEMBER 18, 2016 7:30 am – 7:30 pm Registration Open 8:30 am – 12:00 pm

Statistics Committee Workshop: Data Analysis for Microbiological Method Validation Studies Expert Review Panel – SPSFAM Kombucha TDLM Training Session: Method Validation and Statistics—A Case Study TDRM Workshop: Estimation of Measurement Uncertainty and Reference Materials Exhibit Hall Grand Opening and President's Welcome Reception

1:30 pm – 3:30 pm

3:00 pm – 3:30 pm 3:00 pm – 3:30 pm

1:00 pm – 3:00 pm

1:00 pm – 4:30 pm

3:30 pm – 5:00 pm

3:00 pm – 4:30 pm

3:30 pm – 5:00 pm

7:00 pm – 9:00 pm

MONDAY, SEPTEMBER 19, 2016

3:30 pm – 5:00 pm

7:00 am – 8:00 am

TDRM Executive Committee Meeting

3:30 pm – 5:00 pm

7:30 am – 5:00 pm 8:00 am – 8:30 am

Registration Open

Exhibitor Presentation: Pickering Laboratories AOAC INTERNATIONAL Board of Directors Meeting

4:00 pm – 6:00 pm

8:15 am – 10:15 am

5:00 pm – 5:30 pm

Exhibitor Presentation: VUV Analytics, Inc. New Member Welcoming Reception

9:00 am – 9:30 am

Exhibitor Presentation: MilliporeSigma

5:00 pm – 6:30 pm

9:15 am – 10:15 am Latin America Section Business Meeting 10:00 am – 10:30 am Exhibitor Presentation: Shimadzu Scientific Instruments 10:00 am – 10:30 am Continental Breakfast 10:30 am – 12:00 pm Keynote Address and Awards Ceremony 12:00 pm – 1:00 pm Poster Author Presentations 12:00 pm – 5:00 pm

5:00 pm – 6:30 pm 5:00 pm – 7:00 pm 5:00 pm – 7:00 pm

ALACC Meeting

Juice and Juice Products Meeting

Chemical Contaminants and Residues in Food Community Meeting Cosmetic and Color Additives Meeting Marine and Freshwater Toxins Community Meeting

5:00 pm – 7:00 pm

5:00 pm – 7:30 pm

Poster Presentations: Analysis of Foodborne Contaminants and Residues, Authenticity, Environmental Analysis, and Food Nutrition and Food Allergens

6:00 pm – 7:00 pm 6:00 pm – 7:00 pm 6:30 pm – 7:30 pm 6:30 pm – 7:30 pm 6:30 pm – 8:30 pm

Taiwan Section Business Meeting

Japan Section Business Meeting

Reception for TDLM Members

12:00 pm – 5:00 pm Exhibit Hall Open 12:15 pm – 12:45 pm Exhibitor Presentation: SCIEX 1:00 pm – 1:30 pm H.W. Wiley Award Address 1:30 pm – 3:00 pm Wiley Award Symposium:

Central Section Business Meeting

Research Institute Expert Review Panel Joint Asian Sections Business Meeting

7:00 pm – 8:00 pm

New Analytical Tools to Solve Challenges in Contaminant and Adulterant Analysis

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September 18–21, 2016

Sheraton Hotel, Dallas, Texas

TUESDAY, SEPTEMBER 20, 2016 7:15 am – 8:15 am

1:30 pm – 2:30 pm

TDLM Executive Committee Meeting Contaminants Subgroup Meeting- Metals Exhibitor Presentation: Alkemist Labs Symposium: Development of LC- MS/MS Methods and Reference Materials for the Analysis of Food Allergens Roundtable: Advancing Regulatory Science in Food Testing—Sound Measurement, Analytical Science, Sampling, and Quality Systems toward Food Safety Regulation Refreshment Break

Exhibitor Presentation: Waters Corporation

1:30 pm – 3:00 pm

7:30 am – 5:00 pm 7:45 am – 8:15 am 8:15 am – 9:45 am

Registration Open

2:00 pm – 2:30 pm 2:00 pm – 2:30 pm

Refreshment Break

Symposium: Fighting against Drug/Food Fraud and Adulteration—A Global Business Symposium: Oral Posters from Dietary Supplements and Botanicals Symposium: Improved Methodologies for Performing Quantitative Collaborative Studies Expert Review Panel—Microbiology Methods

3:00 pm – 4:30 pm

8:15 am – 9:45 am

3:00 pm – 4:30 pm

8:15 am – 9:45 am

8:30 am – 12:00 pm

3:00 pm – 4:30 pm

Roundtable: “Seed to Shelf” Analytical Roundtable for Regulators and the

8:30 am – 5:00 pm 9:00 am – 11:00 am

SPIFAN Expert Review Panel

Water/Wastewater Community Meeting

Regulated—Analytical Methods, Botanical Quality/Safety, FSMA and Dietary Supplements cGMP

9:45 am – 10:15 am Exhibitor Presentation: Microbiologics 10:00 am – 10:30 am Refreshment Break 10:00 am – 12:00 pm Committee on Statistics Meeting

4:30 pm – 5:00 pm 4:30 pm – 6:00 pm

Exhibitor Presentation: Metrohm

Contaminants Subgroup Meeting- Environmental and Emerging Contaminants

4:30 pm – 6:00 pm 4:30 pm – 7:30 pm 4:45 pm – 6:45 pm 5:00 pm – 6:00 pm 5:00 pm – 6:30 pm

Membership Committee Meeting

10:00 am – 5:00 pm

Poster Presentations: Analysis of Non-Foodborne Contaminants and Residues, Detection and Measurement of Natural Toxins, and Microbiological Methods

Mycotoxin Community Meeting

Food Allergen Community Meeting

TDRM Members Meeting

10:00 am – 5:00 pm Exhibit Hall Open 10:15 am – 11:45 am Symposium: Control of

Europe Section Executive Committee Meeting TDRM Members Reception, sponsored by Merieux NutriSciences

Precautionary Allergen Labeling – What Have We Done? 10:15 am – 11:45 am Symposium: Current Approaches in Authentication and Adulteration for Herbal and Dietary Supplements (HDS) 10:15 am – 11:45 am Symposium: New Blood

6:00 pm – 7:00 pm

6:15 pm – 7:45 pm

Contaminants Subgroup Meeting- Pesticides

6:30 pm – 7:30 pm

China Section Business Meeting

2016—Developing Methods for the Detection of Chemical Analytes, Residues, and Contaminants Contaminants Subgroup Meeting- Veterinary Drugs

11:45 am – 1:15 pm

12:00 pm – 1:00 pm 12:00 pm – 1:00 pm

Poster Author Presentations

Exhibitor Presentation: Agilent Technologies

12:30 pm – 2:30 pm 1:00 pm – 1:30 pm

Committee on Sections Meeting

Exhibitor Presentation: bioMérieux Inc. AOAC Research Institute Advisory Council Meeting

1:00 pm – 4:00 pm

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WEDNESDAY, SEPTEMBER 21, 2016 7:30 am – 8:00 am Exhibitor Presentation: Thermo Fisher Scientific 7:45 am – 8:15 am Refreshment Break 8:00 am – 10:00 am Expert Review Panel for Proprietary Food Allergens—Gluten 8:00 am – 12:00 pm Registration Open 8:15 am – 9:45 am Symposium: Mycotoxin News—Ready for the Future 8:15 am – 9:45 am

Symposium: Food Allergen and Gluten Analysis by LC- MS—Where Are We?

8:15 am – 9:45 am

Symposium: Facing the Analytical Challenges of Pesticide Residue Analysis—Unknowns, Difficult Pesticides/Matrices and High Resolution MS

12:00 pm – 12:30 pm Exhibitor Presentation: Randox Food Diagnostics 12:00 pm – 1:00 pm Poster Author Presentations 1:00 pm – 2:30 pm Symposium: Carbohydrate Analytical Methods and Labeling 1:00 pm – 2:30 pm

9:45 am – 10:15 am

Exhibitor Presentation: LGC Standards

TDRM Symposium: How to Compare a Certified Value with an Analytical Result and How to Estimate Measurement Uncertainty (MU) Symposium: I Know what you Ate and where it Came from! TDLM Symposium: Strategies for Internal Audits—Effective, Efficient, Economical Symposium: Method Validation and Method Performance Criteria of Chemical Analysis AOAC INTERNATIONAL Stakeholder Panels Update: ISPAM, SPADA, SPDS, SPIFAN, and SPSFAM AOAC INTERNATIONAL Business Meeting Refreshment Break

10:00 am – 10:30 am Refreshment Break 10:00 am – 12:00 pm AOAC Research Institute Board of Directors Meeting 10:00 am – 5:00 pm Poster Presentations: Botanicals and Dietary Supplements, Cosmetics and Color Additives, Emerging Issues in Food Safety and Security, General Methods, Quality Assurance and Accreditation, and Performance Tested Methods TM 10:15 am – 11:45 am Symposium: Hot Topics in Metals Analysis 10:15 am – 11:45 am Symposium: Recent Advances in Environmental Testing of Foodborne Pathogens 10:15 am – 11:45 am Symposium: Updates in Cannabis Including the Complexities of Pesticides 11:45 am – 1:00 pm Technical Programming Council Meeting

1:00 pm – 2:30 pm

2:30 pm – 3:00 pm 3:00 pm – 4:30 pm

3:00 pm – 4:30 pm

3:00 pm – 4:30 pm

4:30 pm – 6:00 pm

8:00 pm – 11:00 pm

Annual Meeting Closing Reception

THURSDAY, SEPTEMBER 22, 2016 8:00 am – 12:00 pm Editorial Board Meeting 8:30 am – 12:00 pm Fall 2016 FIAC Share Group Meeting 10:00 am – 6:00 pm Official Methods Board Meeting

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September 18–21, 2016

Sheraton Hotel, Dallas, Texas

WILEY AWARD

WILEY AWARD ADDRESS ADVANCED STRATEGIES IN FOOD QUALITY, SAFETY, AND AUTHENTICITY CONTROL MONDAY, SEPTEMBER 19, 2016  |  1:00 PM – 1:30 PM Jana Hajšlová, Department of Food Analysis and Nutrition, Institute of Chemistry and Technology, Prague, Czech Republic In this year’s Wiley Award Address, at the 130th AOAC Annual Meeting and Exposition, in Dallas, Texas, USA, the recipient of the 2016 Harvey W. Wiley Award Jana Hajšlová , who is a research scientist at the Institute of Chemical Technology,

Prague, Czech Republic, will reflect on technical advances and challenges in food quality, safety, and authenticity control. On Monday, September 19, Hajšlová will present on the progress to date in food analysis, ongoing projects, and collaboration with AOAC. The field of food analysis has progressed significantly in recent decades, contributing to improved consumer health and reduced economic losses due to food fraud. Advances in instrumentation have driven improved method performance parameters. Data handling has also made considerable progress thanks to advanced software and databases. In addition, new strategies in food analysis have been developed, implemented, and tested in operational environments using, for example, ‘omics’ technologies, bioassay systems, mathematical modeling, quantitative structure-activity relationship models, and threshold of toxicological concern. For detecting contaminants and residues in food, notable innovations have changed the world of laboratory instrumentation. In the past, relatively low-resolution chromatography coupled with various element/group selective detectors was used. Today, validated methods based on high-resolution chromatographic separation followed by selective mass spectrometric (MS) detection are commonly used in trace analysis. Hundreds of analytes can make up the target list. Although this advanced instrumentation is widely available in modern laboratories, determination of possibly co- occurring groups of contaminants and residues is rarely carried out today in a single run. During the Wiley Award Address, Hajšlová will explain how advanced strategies are still needed for simultaneous determination of trace-level compounds. Such strategies are specifically needed for LC-MS-based methods used for trace analysis of emerging contaminants, including pesticide residues, mycotoxins, and natural toxins. To address this challenge, Hajšlová will examine how full-scanning, high-resolution mass spectrometry (HRMS) is becoming the preferred technology by laboratories for both qualitative and quantitative food analysis. This instrument can increase laboratory throughput, decrease sample handling workload, and, at the same time, address concerns on emerging contaminants. HRMS has begun to replace unit resolution main tandem mass spectrometry (using triple quadrupole mass analyzers) as the “gold standard.” HRMS offers major benefits such as nontarget screening (including a search of ´unknowns´) and retrospective data mining. Another technology more and more routinely used in food analysis for determination of sample composition, including minor components, is multi-dimensional separation, namely GCxGC coupled with time of flight detectors (TOF). It offers increased resolution for analysis of minor components and significantly reduces the number of false-positive/ false-negative results. Recently, added separation dimension has been applied, by inserting ion mobility (IM), to LC-MS systems. This technology also offers enormous potential and has opened the door to many challenging applications in food analysis. Isomers, conformers, and isobars can be resolved; cleaner mass spectra offer unbiased identification; and information can be obtained on molecules shape based on their differential behavior or velocity in an electric field.

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The introduction of HRMS in food analysis has been associated with the rapid development of various ambient techniques using various ionization sources. Direct Analysis in Real Time (DART) is becoming one of the techniques most widely used. Hajšlová will explain that by omitting the separation step, rapid screening strategies are being developed to detect suspect samples for follow-up examination. Finally, one of the most recent HRMS-based strategies developed in food analysis is metabolomics fingerprinting and profiling. Metabolomics, a comprehensive analysis of the metabolome, focuses on the broadest possible range of small molecules (<1200 Da) without a particular bias to specific groups of metabolites. This technology indeed represents a challenging tool in food authentication. Using multivariate statistics analysis may help to identify specific (bio)markers used for rapid laboratory control. For those attending the 130th AOAC Annual Meeting and Exposition, you do not want to miss this year’s Wiley Award Address. For more information about the 2016 Annual Meeting, contact meetings@aoac.org.

About Jana Hajšlová Jana Hajšlová is an expert in food chemistry and analysis with over 35 years of experience. Since 2010, she has headed the Department of Food Chemistry and Analysis at the Institute of Chemical Technology (ICT) in Prague, Czech Republic. Her work focuses on analysis of food and natural products, chemical food safety, separation methods in organic trace analysis, analysis of biologically active compounds in biotic matrices, and advanced food analysis. She began her career at ICT first as a research chemist (1979–1986), then as associate professor (1990–1996), and professor (1997–2010). Hajšlová served as president of the AOAC Central European Section from 1996-1999. In addition to the 2016 Harvey W. Wiley Award, she received an AOAC Study Director of the Year award in 2013 for the study, “Determination of Polycyclic Aromatic Hydrocarbons (PAHs) in Seafood Using Gas Chromatography-Mass Spectrometry.” The method ( 2014.08 ) was awarded Method of the Year in 2014. Hajšlová is a member of the scientific board for the Institute of Life Sciences (ILSI); scientific board for the Academy of Science of the Czech Republic (2014–present); international editorial board of the journal Food Additives and Contaminants; Member States Steering Group for a “European Human Biomonitoring Initiative” (2015–present); expert group for networking of European Union (EU) research with global partners (2014-present); COST (European Cooperation in Science and Technology), Committee for Agricultural Sciences/Agricultural Technology (2015– present); Phytosanitary and Environmental

Board assisting RASFF in Czech Republic (current); and Scientific Committee on Food, Czech Republic (current). She has served on several European Union (EU) committees (Advisory Group on Food Quality and Safety for the EU 6th Framework Program, 2006-2007; Scientific Committee on Emerging and Newly Identified Health Risks, 2007-2008; national delegate for the EU 7th Framework Research Program Committee for Food, Agriculture and Fisheries, Biotechnology, 2008-2013; Societal Challenge 2: Food Security, Sustainable Agriculture and Forestry, Marine, Maritime and Inland Water Research and the Bioeconomy (2014-present). She served as the World Health Organization’s (WHO) national contact point for Global Environmental Monitoring Program (1992–1997). She has served on the boards of the Czech Institute for Accreditation, Czech Chemical Society, and Czech Society for Chemistry and Toxicology of the Environment. In 2005, Hajšlová received the ICT Rector award for excellence in research in the area of food chemistry and analysis. The following year, she was a recipient of the Czech Minister of Education award for outstanding scientific service in the implementation of novel analytical strategies in chemical food safety control. She has published about 260 research papers on organic contaminants and chemical food safety. Hajšlová earned a Master’s degree in milk and fats technology from ICT in 1975 and a Ph.D. in food chemistry and technology from ICT in 1979.

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September 18–21, 2016

Sheraton Hotel, Dallas, Texas

KEYNOTE ADDRESS

U.S. PARTICIPATION IN CODEX ALIMENTARIUS, THE ROLE OF STANDARD DEVELOPING ORGANIZATIONS MONDAY, SEPTEMBER 19, 2016  |  10:30 AM – 12:00 PM Greg Noonan, Ph.D., Director, Division of Bioanalytical Chemistry Food and Drug Administration, U.S. Food and Drug Administration ‘Codex Alimentarius ’, or the “Food Code”, primary goal is to protect consumer health by developing and implementing international standards, codes of practice, and guidelines related to safe and high quality food. The U.S., led by the U.S. Codex

Office (USDA), engages with the 180 plus members of Codex Alimentarius through involvement with nearly 20 General Subject and Commodity Committees. A critical part of the U.S. engagement relies on a variety of stakeholders, including consumers, NGOs, industry and Standard Development Organizations (SDOs) such as AOAC INTERNATIONAL. While safety can’t be tested into food, methods of analysis are a critical component to verifying that food meets both safety and quality standards agreed to by international trading partners. AOAC INTERNATIONAL Official Methods are heavily relied upon and have been “endorsed” by the Codex Committee on Methods of Analysis and Sampling (CCMAS) for inclusion in numerous Codex Standards. However, the development of new commodity standards or new analytical methods means that methods are often reviewed and updated. The acceptance of new methods into Codex Standards requires careful planning, often with multiple Codex Committees, an understanding of Codex procedural rules and patience. AOAC INTERNATIONAL’s continued engagement with U.S. Delegates to Codex Committees and yearly participation in CCMAS is vital to ensuring newly developed methods are properly considered by Codex Committees.

About Dr. Noonan Dr. Gregory Noonan joined the U.S. Food and Drug Administration in 2002 and is currently the Director of the Division of Bioanalytical Chemistry (DBC) in the Office of Regulatory Science. The Division of Bioanalytical Chemistry contains over 35 scientists performing research and developing analytical methods in numerous subject areas, including, toxic elements analysis, immunodiagnostic and DNA- based allergen detection, radionuclides, pesticide analysis, mycotoxin analysis, dietary supplements and botanicals, nutritional ingredients and cosmetics. Prior to becoming Director, Dr. Noonan was a Research Chemist in the Method Development Branch of the Division of Analytical Chemistry. His research focused on developing methods for the determination of food additives, including indirect

additives, and process induced contaminants. Dr. Noonan also serves as the U.S. Delegate to the Codex Committee on Methods of Analysis and Sampling (CCMAS), where he chairs the Working Group on the Endorsement of Methods. Dr. Noonan received his PhD in Chemistry from Michigan State University in 1996. After graduation he worked for the Diagnostic Division of Abbott Laboratories, where he developed diagnostic immunoassays for Hepatitis A, B and C and HIV. After leaving Abbott Laboratories and prior to joining the FDA, he was a postdoctoral fellow in the Civil and Environmental Engineering department of the Massachusetts Institute of Technology, where he studied the fate and transport of polar, water soluble environmental contaminants.

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Pre-Meeting Stakeholder Panels AOAC has established several consensus panels to empower the industry(s) to take the lead on providing solutions to global issues. These panels serve as a science-based, open and neutral forums where global stakeholders from government, industry and academia convene to identify issues and articulate standard method performance requirements (SMPRs) needed for eliminating trade barriers; substantiating health claims; and meeting and/or establishing regulatory requirements. These panels will be meeting on September 16–18, 2016, prior to the AOAC Annual Meeting & Exposition. These meetings are open to all interested attendees. Register separately for these panels and plan to attend.

STAKEHOLDER PANEL ON DIETARY SUPPLEMENTS (SPDS) September 16-17, 2016 The dietary supplements community is working collaboratively to identify and prioritize ingredients and develop voluntary consensus standards. For more information, visit www.aoac.org and click the tab “Standards Development”, then “Stakeholder Panel on Dietary Supplements (SPDS)”. Contact: Dawn Frazier at dfrazier@aoac.org or 301-924-7077, ext. 117.

STAKEHOLDER PANEL ON INFANT FORMULA AND ADULT NUTRITIONALS (SPIFAN) September 17, 2016 The global infant formula community is in the process of developing voluntary consensus standards for global dispute resolution methods. For more information, visit www.aoac.org and click the tab “Standards Development”, then “Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN)”. Contact: Alicia Meiklejohn at ameiklejohn@aoac.org or 301-924-7077, ext. 101. INTERNATIONAL STAKEHOLDER PANEL ON ALTERNATIVE METHODS (ISPAM) September 18, 2016 ISPAM is focusing on developing voluntary consensus standard method performance requirements (SMPR ® ) for food allergen methods. For more information, visit www.aoac.org and click the tab “Standards Development”, then “International Stakeholder Panel on Alternative Methodology (ISPAM)”. Contact: Krystyna McIver at kmciver@aoac.org or 301-924-7077, ext. 111.

STAKEHOLDER PANEL ON STRATEGIC FOOD ANALYTICAL METHODS (SPSFAM) September 18, 2016 AOAC is bringing the food industry together to lead the charge to develop much needed standards and methods that promote food safety, food security, and facilitate trade. For more information, visit www.aoac.org and click the tab “Standards Development”, then “Stakeholder Panel on Strategic Food Analytical Methods (SPSFAM). Contact: Dawn L. Frazier at dfrazier@aoac.org or 301-324-7077, ext. 117.

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September 18–21, 2016

Sheraton Hotel, Dallas, Texas

THE AOAC EXPOSITION Designed to be an integral part of your Annual Meeting experience, the AOAC Exposition has a superb range of new services and technologies to examine. Over 50 leading suppliers to the analytical communities will be onsite. The Exposition offers an outstanding opportunity to learn about resources available to enhance both your individual and company performance.

EXHIBIT HALL HOURS Exhibit Hall Grand Opening & President’s Welcome Reception

Sunday, September 18, 2016 Monday, September 19, 2016 Tuesday, September 20, 2016

7:00 pm – 9:00 pm 12:00 pm – 5:00 pm 10:00 am – 5:00 pm

EXHIBITORS Following is a list of exhibitors confirmed as of press time. Please visit the AOAC web site at www.aoac. org to see additional exhibitors as they are added. If your organization is interested in exhibiting and/or sponsoring an event at the meeting, please contact Lauren Chelf at lchelf@aoac.org or 240-912-1449 . A2LA – American Association for Laboratory Accreditation Agilent Technologies, Inc. Alkemist Labs & Extrasynthese Phytochemicals BUCHI Corporation CAMAG Scientific, Inc. Cedarlane CEM Corporation Cerilliant ELISA Technologies, Inc. Elution Technologies Glas-Col, LLC Hanna Instruments Labtopia, Inc. Leco Corporation LGC Standards Megazyme Metrohm USA Microbiologics Microbiology International MilliporeSigma NACALAI TESQUE, Inc. NIST/ORM Phenomenex Pickering Laboratories, Inc. Q Laboratories, Inc. Randox Food Diagnostics SCIEX Shimadzu Scientific Instruments, Inc. SPEX SamplePrep Teledyne Tekmar Thermo Scientific USDA, FSIS, Accredited Alpha Biosciences, Inc. American Proficiency Institute ANKOM Technology

Horizon Technology, Inc. Interscience Laboratories Inc. IsoSciences Laboratory Accreditation Bureau

NSF International NSI Lab Solutions PerkinElmer

bioMérieux Inc. Bioo Scientific Biotage Bruker Corporation

Laboratory Program (ALP) VICAM, A Waters Business

Perry Johnson Laboratory Accreditation Inc. (PJLA)

VUV Analytics, Inc. Waters Corporation

AOAC has listened to your requests for additional time to visit the Exhibit Hall. AOAC will not hold scientific sessions from 11:45am – 3:00pm on Tuesday, September 20 . Please use this time to visit the wonderful collection of vendors in the Hall. EXHIBITOR/PARTNER PRESENTATIONS AOAC Annual Meeting exhibitors and partners will hold Presentations throughout the Meeting. This venue allows more in-depth interaction and one-on-one contact between attendees and exhibiting companies. Companies will be showcasing new products, new technologies, and offering product demonstrations--you won’t want to miss this opportunity. Stop by an Exhibitor/Partner Presentation and learn more about the following companies’ products and services.

Monday, September 19, 2016 8:00am – Pickering Laboratories 9:00am – MilliporeSigma 10:00am – Shimadzu Scientific Instruments 12:15pm – SCIEX 3:00pm – Covance Laboratories 5:00pm – VUV Analytics, Inc.

Tuesday, September 20, 2016 7:15am – Waters Corporation 9:45am – Microbiologics 12:00pm – Agilent Technologies

Wednesday, September 21, 2016 7:30am – Thermo Fisher Scientific

9:45am – LGC Standards 12:00pm – Randox Food Diagnostics

1:00pm – bioMérieux Inc. 2:00pm – Alkemist Labs 4:30pm – Metrohm

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SCIENTIFIC SESSIONS

SUNDAY, SEPTEMBER 18, 2016 8:30 am – 12:00 pm

The workshop will be given in the following parts. Part I The test method will be a quantitative method used from the Limit of Quantitation to a high concentration. The acceptance criteria will be given. This means the following performance characteristics need to be included in the method validation: selectivity, linearity, trueness (bias) (accuracy), repeatability, intermediate precision, limit of detection, limit of quantitation, measurement uncertainty. The test method will be presented and then the attendees will discuss what they would validate and how. They will design the experiments to be performed for the method validation. Part II The experiments and statistical tools for evaluating the experiments for the case study will be presented. Part III The DOE (ANOVA), or AOAC ruggedness test, or simplex DOE will be presented. Part IV The experimental results will be compared to the acceptance criteria. A brief method validation report will be presented. An EXCEL spreadsheet will be distributed to the attendees. These EXCEL files will be used, so the attendees should bring their own laptops to the workshop. CO-CHAIR: Jane Weitzel, Consultant CO-CHAIR: Franz Ulberth, European Commission - Institute for Reference Materials and Measurements • Jane Weitzel, Independent Consultant Part I Introduction to the Case Study • Franz Ulberth, European Commission - JRC - IRMM Part II Experiments and Statistical Evaluation for Method Validation • Susan Audino, Audino & Associates, LLC Part III Simplex Experiments for Method Validation • Jane Weitzel, Independent Consultant Part IV The Method Validation Report

Statistics Committee Workshop: Data Analysis for Microbiological Method Validation Studies This workshop will explain and teach participants the statistical data analyses used in microbiological method validation studies as required by AOAC Guidelines Appendix J. Appendix J was adopted in 2012 as the guideline for validating AOAC OMA and PTM methods for microbiological analytes. The workshop will cover procedures and software used for both qualitative and quantitative methods for single-lab and multi-lab studies. The workshop will be targeted for method developers, kit manufacturers, ERP members, method reviewers, and method users. New and improved statistical workbooks will be introduced and demonstrated at this workshop. CHAIR: Paul Wehling, Medallion Laboratories/ General Mills • Paul Wehling, Medallion Laboratories/ General Mills • Sharon Brunelle, AOAC Technical Consultant • Maria Nelson, AOAC Technical Consultant TDLM Training Session: Method Validation and Statistics—A Case Study This workshop will explain the basic statistics necessary for method validation such as regression analysis, ANOVA for precision estimation, and Design of Experiments (DOE). There are many guides and there have been many training sessions on method validation. This workshop will build on these by presenting a completed method validation for a specific case. The HOW TO use statistics when validating a method will be presented and emphasized. 1:00 pm – 4:30 pm

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September 18–21, 2016

Sheraton Hotel, Dallas, Texas

3:00 pm – 4:30 pm

Official Control of Food and Food Supplement Adulteration—Recent Examples

TDRM Workshop: Estimation of Measurement Uncertainty and Reference Materials The estimation of measurement uncertainty (MU) is an important, but often neglected part of method development and method validation. In this workshop, experts in the fields of environmental, agricultural, food, supplement, and clinical analysis will work through examples for the estimation of MU of analytical results in relevant matrix based samples. Different strategies for estimation of MU will be explained as well as the use of MU in relation to certified reference materials (CRMs) and proficiency testing (PT). CO-CHAIR: Catherine Rimmer, National Institute of Standards and Technology CO-CHAIR: Sidney Sudberg, Alkemists Laboratories

• Katerina Mastovska, Covance Laboratories Inc. New Analytical Tools to Solve Old and New Challenges in Contaminant Analysis Laboratory Accreditation – Progress towards the Nation’s Integrated Food/Feed Safety System The U.S. FDA initiated formation of the Partnership for Food Protection (PFP) in 2008 to further the goal of creating an Integrated Food Safety System. The PFP plays an integral role in implementing the Food Safety Modernization Act (FSMA), particularly as it pertains to “improve the effectiveness of federal, state, and local partnerships to coordinate food safety and defense resources and reduce the incidence of foodborne illness.” FSMA stresses the importance of quality testing standards and directs FDA to establish a program for laboratory accreditation. In 2012, FDA entered into five-year cooperative agreements with 31 state food- testing laboratories to either attain ISO/IEC 17025:2005 accreditation (23) or expand/maintain existing ISO accreditation (8). FDA also awarded a five-year cooperative agreement to the Association of Public Health Laboratories (APHL) to support laboratory accreditation in collaboration with the Association of Food and Drug Officials (AFDO) and the Association of American Feed Control Officials (AAFCO). In 2015, an additional 26 food/feed testing laboratories were awarded funding to obtain ISO/IEC 17025 accreditation. ISO/IEC 17025 accreditation attests to the competency and technical capability of a laboratory, leading to results which are defensible to a recognized standard. Accreditation supports the traceability and accountability of results generated by a laboratory that may be made available for consideration by federal agencies for enforcement actions. Investment in laboratory accreditation for the Nation’s regulatory food/feed testing laboratories will work to protect the public health by providing greater laboratory capacity of quality data submitted to regulatory food agencies. CO-CHAIR: Yvonne Salfinger, Association of Public Health Laboratories CO-CHAIR: Ruiqing Pamboukian, U.S. Food and Drug Administration • Ruiqing Pamboukian, U.S. Food and Drug Administration FDA Perspectives on ISO/IEC 17025 Accreditation for Food/Feed Regulatory Testing Laboratories • Sharon Shea, Association of Public Health Laboratories Association Efforts to Integrate the Nation’s Food Laboratories • Dirk Shoemaker, Nebraska Department of Agriculture Laboratory A State’s Perspective on ISO/IEC 17025 Accreditation

MONDAY, SEPTEMBER 19, 2016 1:30 pm – 3:00 pm

Wiley Award Symposium: New Analytical Tools to Solve Challenges in Contaminant and Adulterant Analysis The Wiley Award Symposium will honor the 2016 Wiley Award recipient Prof. Jana Hajšlová. The speakers are Prof. Hajšlová’s long-term collaborators. They will discuss new analytical tools that can be used to solve new and old challenges in chemical contaminant and adulterant analysis. CHAIR: Katerina Mastovska, Covance Laboratories Inc. • Rudolf Krska, University of Natural Resources and Life Sciences, Vienna (BOKU) Novel Infrared Spectroscopic and Mass Spectrometric Tools to Identify and Quantify Novel Secondary Metabolites in Cereals and Other Foods • Michel Nielen, RIKILT - Institute of Food Safety Planar Bioaffinity Arrays for the Analysis of Mycotoxins in Beer • Petr Cuhra, Czech Agriculture and Food Inspection Authority (CAFIA)

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Culture Independent Detection Methods: Scope and Validation Strategies for Routine Application in Food Laboratories Culture independent detection (CID) methods for pathogen detection are of growing interest to the food safety stakeholders, specifically to the meat industry. More recently some of the public health surveillance databases have also started incorporating the results from culture-independent methods. These methods do not require cultural isolation and confirmation of pathogens in a sample. Thus, these are unconventional for routine testing in food microbiology laboratories. There is a need to further discuss the scope, advantages, disadvantages, and a road-map for verification and validation strategies of the culture independent methods. This session will provide the perspectives of food industry and regulatory agencies on the application of culture independent methods in food laboratories. The session will also discuss at length if the culture independent methods can be implemented in routine food microbiology applications, outbreak investigations and public health surveillance and management. CO-CHAIR: Hari Dwivedi, bioMerieux, Inc. CO-CHAIR: Patrice Arbault, Nexidia • Hari Dwivedi, bioMerieux, Inc. Opportunities and Challenges in Using CID for Routine Applications in Food Safety and Public Health • Pamela Wilger, Cargill, Inc, Scope and Verification of CID for Industrial Application- an Example from the Meat Industry • Leslie Thompson, Vanguard Sciences Validation and Verification Approaches for Routine Use of CID in Food Contract Labs • Thomas Hammack, U.S. Food and Drug Administration Regulatory Perspective and Insight on the Future Road- Map for the Validation Strategies of Culture Independent Methods Workshop—Technical Committee for Juice and Juice Products (TCJJP): The Basics of Fruit Juice Quality Assessment Fruit juice producers face a number of challenges to bring high quality and nutritious products to the consumer, and the Food Safety and Modernization Act (FSMA) of 2010 only adds another layer of complexity. The goal of this workshop is to provide novice through the experienced practitioners an understanding of the latest, basic information on assessing the quality of the fruit juices they purchase as ingredients for their products. The workshop will cover how to assess the authenticity of juice in this day of new and exotic or other high cost fruits, how to accurately measure and reflect the sugar content of juice as a result of current health concerns and perceptions about sugar in the diet, and how to ensure the safety of 3:30 pm – 5:00 pm

products due to pesticides, heavy metals and other trace organic and inorganic contaminants. The session will be followed by the annual business meeting of the Technical Committee for Juice and Juice Products that all workshop attendees are invited to attend for further discussion on these and many other current topics of interest to the fruit juice community. CO-CHAIR: David Cunningham, Ocean Spray Cranberries, Inc. CO-CHAIR: Ramin Jahromi, Eurofins Scientific Group • Eric Jamin, Eurofins Scientific Inc. High Resolution NMR and MS: Powerful and Complementary Tools for Untargeted Authentication of Fruit Juice Products • Don Giampetro, iTiTropicals, Inc. Sourcing Tropicals—Just another Day in Tropical Paradise • Dana Krueger, Krueger Food Laboratories, Inc. Standard Methods for Sugar Analysis in Fruit Juices • Kai Liu, Eurofins Scientific Inc. Newer Chromatographic Methods of Sugar Analysis • James (Mike) Farrow, U.S. Food and Drug Administration Fruit Juice Adulteration and Contamination, an FDA Perspective—Part I • Ruiqing Pamboukian, U.S. Food and Drug Administration Fruit Juice Adulteration and Contamination, an FDA Perspective—Part II Botanical Dietary Supplement Ingredient Identity Authentication: Determining Appropriate Reference Materials for Botanicals and their Extracts The selection and appropriate use of botanical reference materials (BRMs) are the essential parts of dietary supplement botanical ingredient authentication activities. Botanical dietary supplement ingredients fall into one of two categories – dried plant parts and their more highly processed extracts. Dried plant part ingredients have undergone only physical processing steps such as milling to reduce particle size. More highly processed botanical ingredients have undergone further processing steps such as extraction, fractionation, distillation, fermentation, etc. or even being combined with other components to form compound ingredients. BRMs must be selected to match the essential character of the different botanical materials that are to be compared to them. This session covers important considerations in determining appropriate BRM selection and use. Un- extracted botanical material requires the use of dried BRM, the identity has been established by a botanist. Processed materials require highly-characterized reference materials that are fit for their intended use. They need to be sufficiently homogeneous and stable with respect to

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September 18–21, 2016

Sheraton Hotel, Dallas, Texas

one or more specified properties that have been established to be fit for their intended use in a measurement process, both qualitatively and quantitatively.

This session is intended to further develop our AOAC Community on Cosmetics and Color Additives. CO-CHAIR: Bhakti Petigara Harp, U.S. Food and Drug Administration CO-CHAIR: Kristie Laurvick, U.S. Pharmacopeia (USP) • Wei Zhu, U.S. Pharmacopeial Convention Modernization of Standards for Synthetic Colorants: Analytical Methods and Reference Material • Robert Sheridan, New York State Department of Agriculture and Markets Food Laboratory Synthetic Colors in Food; Past and Present • Mark Goldschmidt, Sensient Technologies Establishing Quality and Safety Standards on Colors Exempt from Certification • Bhakti Petigara Harp, U.S. Food and Drug Administration Evaluation of Potential Color Adulteration of Green Table Olives

Numerous technologies are available for the identification and authentication of botanical materials including assessing morphological characteristics via macroscopic and microscopic methods, examining the plants genome via DNA barcoding or sequencing, assessing chromatographic profile “fingerprints” of the material’s metabolome via HPLC and HPTLC, and spectroscopic analysis of these constituents via NMR analysis, among others. This session proposes to cover the following essential topics by the listed speakers. CO-CHAIR: Yanjun Zhang, Herbalife International of America Inc. CO-CHAIR: Peter Chang, Herbalife International of America Inc. • Wendy Applequist, Missouri Botanical Gardens Supply and Utilization of Botanical Reference Materials • Steven Newmaster, University of Guelph Botanical Species Ingredient Validation Using DNA- Based Molecular Diagnostic Tools • Congmei Cao, Herbalife International of America Inc. Chromatographic Chemical Profiling and Appropriate Use of Botanical Reference Materials (BRMs) for Botanical Ingredient Authentication • James Traub, Waters Corporation Technologies for Botanical Constituent Quantitation • Kimberly Colson, Bruker BioSpin Metabolomic Analysis for Botanical Ingredient Authentication by NMR Synthetic Color Additives – Developing Modern Analytical Methods and Reference Materials Color additives (both synthetic and those derived from natural sources) used in food and cosmetic products in the United States and internationally are often complex formulations that may be difficult to analyze using older analytical tools often cited in compendia and other publications. While some of these color additives require certification by the FDA for sale/use in the United States, others have no such requirement when approved for use in other countries. The current lack of modern analytical testing methods and reference materials may impede international trade and usage of these color additives in food and cosmetic products. Because these products are often subject to additional scrutiny by regulators and food and cosmetic manufacturers, we believe that developing modern analytical techniques for identification, assay, and determination of manufacturing impurities in color additives should be an ongoing effort. This AOAC Scientific Session provides initial briefings that speak to the challenges on both the regulatory and analytical scientific fronts, including these analytical methods.

TUESDAY, SEPTEMBER 20, 2016 8:15 am – 9:45 am Fighting against Drug/Food Fraud and Adulteration: A Global Business Adulteration of pharmaceutical and food products represents a major global challenge and poses a serious public health risk. The globalization of the supply chain has made detection, identification, control, and disposal of counterfeit products extremely difficult. Analytical procedures are critical to identifying and controlling the deliberate substitution of ingredients with inexpensive

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