14
Biophysical Society 58
th
Annual Meeting, San Francisco, California
81-S
ymp
8:45
am
MYOSIN II CONTROLS CELLULAR BRANCHING
MORPHOGENESIS AND MIGRATION IN 3D BY MINIMIZING
PLASMA MEMBRANE CURVATURE. Fischer A. R, Hunter Elliot,
Clare Waterman
, Gaudenz Danuser
82-S
ymp
9:15
am
CONTRACTILITY DRIVEN SELF-ORGANIZATION OF THE
ACTIN CYTOSKELETON.
Alexander D. Bershadsky
83-S
ymp
9:45
am
DYNAMIC ORGANIZATION OF DEVELOPING EPITHELIA.
Frank Julicher
8:15
am
–10:15
am
, R
oom
130/131
Platform
Membrane Protein Structure, Dynamics,
and Interactions
Co-Chairs
Lumelle A. Schneeweis, Bristol-Myers Squibb
Philip Biggin, Oxford University, United Kingdom
84-P
lat
8:15
am
INTEGRATING THE SIGNALS: IMPLICATIONS OF CFTR NBD1
ALLOSTERY TO CYSTIC FIBROSIS.
Dawson E. Jennifer
,
Andrew Chong, Robert Vernon, Rhea Hudson, Patrick Farber,
Julie D. Forman-Kay
85-P
lat
8:30
am
PROBING LIGAND DYNAMICS IN MEMBRANE-BOUND
CYTOCHROME P450 3A4 TO CHARACTERIZE SUBSTRATE
ACCESS AND PRODUCT EGRESS PATHWAYS.
Javier Baylon
,
Emad Tajkhorshid
86-P
lat
8:45
am
CHARACTERIZATION OF CHOLESTEROL AND DRUG LIGAND
INTERACTIONS WITH TRANSLOCATOR PROTEIN 18 KDA
(TSPO) FROM
RHODOBACTER SPHAEROIDES
.
Fei Li
, Lance Valls,
Shelagh Ferguson-Miller
87-P
lat
9:00
am
MONITORING INTRAMEMBRANE PROTEOLYTIC CLEAVAGE
REACTIONS USING ISOTOPE-ASSISTED VIBRATIONAL
INTERROGATIONOF MEMBRANE EMBEDDED (IVIBE) PROTEINS.
Mia Brown
, Renee D. JiJi, Iban Ubarretxena-Bilandia, Jason W. Cooley
88-P
lat
9:15
am
INVESTIGATING LIGAND-MODULATION OF GPCR ACTIVATION
PATHWAYS.
Morgan Lawrenz
, Kai Kohlhoff, Diwakar Shukla,
Greg Bowman, Russ Altman, Vijay Pande
89-P
lat
9:30
am
education
travel
awardee
CRYSTAL STRUCTURE OF MRAY, AN ESSENTIAL MEMBRANE
ENZYME FOR BACTERIAL CELL WALL SYNTHESIS.
Ben C. Chung
, JInshi Zhao, Robert Gillespie, Do Yeon Kwon,
Ziqiang Guan, Jiyong Hong, Pei Zhou, Seok-Yong Lee
90-P
lat
9:45
am
COMBINING MODELLING AND SITE-DIRECTED
MUTAGENESIS TO EXPLORE AGONIST BINDING TO HUMAN
OREXIN RECEPTORS. Alexander Heifetz, Oliver Barker,
G. Benjamin Morris, Richard J. Law, Mark Slack,
Philip C. Biggin
91-P
lat
10:00
am
KINETIC EXCLUSION ANALYSIS (KINEXA) OF AVIDITY
ENHANCEMENT OF A MULTI-VALENT ADNECTIN
BINDING TO CLUSTERED RECEPTORS ON CHO CELLS.
Lumelle A. Schneeweis
, Sandra V. Hatcher, Bryan Barnhart,
Thomas R. Glass, Lin Cheng, Benjamin Blum, Eric Lawrence,
Rolf Ryseck, Ray Camphausen, Bozena M. Abramczyk, Anthony Della Pietra,
Martin J. Corbett, Thomas McDonagh, Michael L. Doyle, James Bryson
8:15
am
–10:15
am
, R
oom
132/133
Platform
Voltage-gated K Channels:
Activation/Inactivation Mechanisms
Co-Chairs
Manuel Covarrubias, Jefferson Medical College of Thomas Jefferson University
Serdar Durdagi, Bahcesehir University, Turkey
92-P
lat
8:15
am
A-TYPE KV4 CHANNEL CLOSED-STATE INACTIVATION IS
MODULATED BY THE TETRAMERIZATION DOMAIN
INTERACTING WITH AUXILARY KCHIP4A. Yi-Quan Tang, Fan
Yang, Jingheng Zhou, Jie Zheng,
KeWei Wang
93-P
lat
8:30
am
TWO-IN-ONE: ACTIVATION AND INACTIVATION AT THE
INTRACELLULAR GATE OF A KV CHANNEL.
Manuel Covarrubias
,
Jeffrey D. Fineberg
94-P
lat
8:45
am
DEVELOPMENT AND VALIDATION STUDIES OF UNIVERSAL
PHARMACOPHORE MODELS FOR HERG CHANNEL OPENERS.
Serdar Durdagi
, Matthew Patterson, Sergei Y. Noskov
95-P
lat
9:00
am
N-TERMINAL REGULATION OF HERG1 K
+
CHANNEL
DEACTIVATION.
Steven J. Thomson
, Angela Hansen,
Michael C. Sanguinetti
96-P
lat
9:15
am
LIPID AFFINITY TO THE VOLTAGE-GATED POTASSIUM
CHANNEL KVAP.
Elise Faure
, Christine Thompson, Rikard Blunck
97-P
lat
9:30
am
A STRUCTURAL DRIVEN KINETIC CYCLE FOR KCSA GATING.
Luis G. Cuello
, D. Marien Cortes, Eduardo Perozo
98-P
lat
9:45
am
STATE-DEPENDENT CROSSLINKING IN IKS DEMONSTRATES
A CLOSED-STATE INTERACTION BETWEEN KCNE1 AT F57
AND KCNQ1 THAT INHIBITS CHANNEL OPENING.
Christopher I. Murray
, Yasmeen Maurice, Jodene Eldstrom,
David Fedida
99-P
lat
10:00
am
MOVING GATING CHARGES THROUGH THE GATING PORE
IN A KV CHANNEL VOLTAGE-SENSOR.
Jerome J. Lacroix
,
Clark H. Hyde, Fabiana V. Campos, Francisco Bezanilla
