1016 / 1578
/
Ø
Very small patient numbers
Ø
How to integrate into systemic treatment ?
Study Patients
Dose
Chemotherapy
Hoyer
2005
Phase II
22
3 x 15Gy
None
Koong
2005
Phase II
17
45Gy CF
1 x 25Gy Boost
5-FU during
CF-RT
Schellenberg
2008
Phase II
16
1 x 25Gy
Between Gem
Schellenberg
2011
Phase II
20
1 x 25Gy
Between Gem
SBRT for locally advanced pancreatic cancer
ESTRO SBRT 2017 - Matthias Guckenberger
9
/
Study Patients Median OS
LC
Hoyer
2005
Phase II
22
5.4
months
57% @ 6m
Koong
2005
Phase II
17
8.3
months
16 / 17
Schellenberg
2008
Phase II
16
11.4 months
81%
Schellenberg
2011
Phase II
20
11.8 months
94% @ 1a
SBRT for locally advanced pancreatic cancer
Ø
(Very) short OS – similar to systemic treatment only
Ø
Interpretation of promising LC considering OS ?
ESTRO SBRT 2017 - Matthias Guckenberger
10