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Biophysical Society 59
th
Annual Meeting, Baltimore, Maryland
T
U
E
S
D
A
Y
2146-P
os
B
oard
B283
DISCONTINUITY BETWEEN THE VOLTAGE-SENSOR AND THE
PORE DOMAIN DOES NOT ABOLISH VOLTAGE-GATING OF
KV10.1 POTASSIUM CHANNEL.
Adam P. Tomczak
, Eva Lörinczi,
Juan Camilo Gomez-Posada, Walter Stühmer, Luis A. Pardo
2147-P
os
B
oard
B284
TWO KCNQ1 MUTATIONS ASSOCIATED WITH FAMILIAL
ATRIAL FIBRILLATION, S140G AND V141M, DEMONSTRATE
DISTINCT VOLTAGE SENSOR PHENOTYPES.
Gary Peng
, Kevin J.
Sampson, Rene Barro-Soria, H. Peter Larsson, Robert S. Kass
2148-P
os
B
oard
B285
MOLECULAR DETERMINANTS OF VOLTAGE SENSOR
DOMAIN ACTIVATION.
Lucie Delemotte
, Vincenzo Carnevale,
Michael L Klein, Marina A. Kasimova, Mounir Tarek
2149-P
os
B
oard
B286
ROLE OF THE VOLTAGE SENSING DOMAIN S1-S4 IN TRPV1
CHANNELS.
Juan Zhao
, Rikard Blunck
2150-P
os
B
oard
B287
SENSING THE ELECTROCHEMICAL K
+
GRADIENT: THE
VOLTAGE GATING MECHANISM IN K2P POTASSIUM
CHANNELS.
Marcus Schewe
, Ehsan Nematian-Ardestani, Thomas
Linke, Klaus Benndorf, Stephen J. Tucker, Markus Rapedius, Thomas
Baukrowitz
2151-P
os
B
oard
B288
CAN CLC-2 CHLORIDE CHANNEL BE ACTIVATED BY
HYPERPOLARIZATION ALONE IN CELLS DIALYZED WITH
NON-PERMEANT ANIONS? José J. De Jesús-Pérez, Alejandra Castro-
Chong, Ru-Chi Shieh, Carmen Y. Hernández-Carballo, Jose A. De
Santiago-Castillo,
Jorge Arreola
2152-P
os
B
oard
B289
MOLECULAR BASIS OF VOLTAGE-DEPENDENT GATING IN
CLC TRANSPORTERS.
Jan-Philipp Machtens
, Matthias Grieschat,
Christoph Fahlke, Alexi K. Alekov
2153-P
os
B
oard
B290
MULTIPHASIC PROFILES: DISCONTINUOUS TRANSITIONS IN
CONDUCTANCE-VOLTAGE DATA FOR ION CHANNELS.
Per Nissen
2154-P
os
B
oard
B291
A HIGHLY COOPERATIVE AND STEEPLY VOLTAGE GATED
CHANNEL TRIPLET.
Shang H. Lin
, Benjamin Wu, Marco Colombini
Ligand-gated Channels II
(Boards B292-B318)
2155-P
os
B
oard
B292
NON-EQUIVALENT LIGAND SELECTIVITY OF AGONIST SITES
IN (
α
4
β
2)2
α
4 NICOTINIC ACETYLCHOLINE RECEPTORS: A KEY
DETERMINANT OF AGONIST EFFICACY.
Simone Mazzaferro
,
Federica Gasparri, karina New, Constanza Alcaino, Isabel Bermudez
2156-P
os
B
oard
B293
DESFORMYLFLUSTRABROMINE POTENTIATES HIGH-
SENSITIVITY
α
4
β
2 RECEPTORS BY INCREASING CHANNEL
OPENING RATE.
Arianna Demmerly
, Brian W. Edmonds
2157-P
os
B
oard
B294
IS THE ACHR A CUCKOO-CLOCK? LOCAL AND REMOTE
INTERACTIONS OF THE
α
M2-3 LINKER IN GATING.
Shaweta Gupta
, Prasad Purohit, Anthony Auerbach
2158-P
os
B
oard
B295
MOLECULAR SIMULATIONS OF MUSCLE ACHR AGONIST
BINDING SITES.
Srirupa Chakraborty
, Tapan K. Nayak, Iva Bruhova,
Wenjun Zheng, Anthony L. Auerbach
2159-P
os
B
oard
B296
DIFFERENCES IN AGONIST ENERGY AT THE
NEUROTRANSMITTER BINDING SITES IN THE
NEUROMUSCULAR ACETYLCHOLINE RECEPTORS.
Tapan K. Nayak
, Anthony Auerbach
2160-P
os
B
oard
B297
INTERACTION OF 7-METHOXYTACRINE-ADAMANTYLAMINE
CHOLINESTERASE INHIBITORS WITH NICOTINIC AND
MUSCARINIC ACETYLCHOLINE RECEPTORS. Ze-Jun Wang,
Vendula Sepsova, Katarina Spilovska, Tasnim S. Mohamed,
Ayman K. Hamouda
2161-P
os
B
oard
B298
STEPCHILD NICOTINE: EFFECT OF THE NAME-GIVING
AGONIST ON MUSCLE-TYPE NICOTINIC ACETYLCHOLINE
RECEPTOR.
Abhilasha Ladha
, Klaus Benndorf, Jana Kusch
2162-P
os
B
oard
B299
THE ROLE OF THE M3 HELIX IN ACHR GATING AND PAM
ACTION.
Aashutosh Vihani
, Prasad Purohit, Anthony Auerbach
2163-P
os
B
oard
B300
MODAL GATING OF MUSCLE ACHRS HAVING LOOP C
MUTATIONS.
Ridhima Vij
2164-P
os
B
oard
B301
DISSECTING THE INHIBITORY AND POTENTIATION EFFECTS
OF DESFORMYLFLUSTRABROMINE ON A MUSCLE-TYPE
NICOTINIC ACETYLCHOLINE RECEPTOR (NACHR).
Tasnim S. Mohamed
, Ze-Jun Wang, Tiffany R. Trevino, Ayman K.
Hamouda
2165-P
os
B
oard
B302
international
travel awardee
EXPLORING ALPHA7 POSITIVE ALLOSTERIC MODULATORS
FROM A SINGLE-CHANNEL PERSPECTIVE.
Natalia D. Andersen
,
Jeremias Corradi, Fernanda Tolosa, Nehuen Gasparini, Hugo R. Arias,
Cecilia B. Bouzat
2166-P
os
B
oard
B303
GATING RITUAL: SIMULATIONS OF GATING IN GLUTAMATE-
GATED CHLORIDE CHANNEL.
Ozge Yoluk
, Stephanie Heusser,
Magnus Andersson, Laura Orellana, Erik Lindahl
2167-P
os
B
oard
B304
AROMATIC RESIDUES IN THE TRANSMEMBRANE HELICES
PLAY AN ESSENTIAL ROLE IN THE HOMOPENTAMERIC
ASSEMBLY OF THE GLUCL
α
.
Anke Dopychai
, Clairentine F. Pokam,
Gunther Schmalzing
2168-P
os
B
oard
B305
OPENING AND SELECTIVITY OF THE GLIC LIGAND-
GATED ION CHANNEL CAN BE TUNED BY MUTATION OF
HYDROPHOBIC RESIDUES IN THE PORE. Özge Yoluk, Stephanie
Heusser, Iman Pouya, Rebecca Howard, Göran Klement,
Erik Lindahl
2169-P
os
B
oard
B306
GLIC-ELIC CHIMERAS HAVE UNEXPECTED
CHARACTERISTICS.
Sarah C. Lummis
, Mona Alqazzaz
2170-P
os
B
oard
B307
ROLE OF THE TRANSMEMBRANE
α
-HELIX M4 IN THE
POTENTIATION OF PENTAMERIC LIGAND-GATED ION
CHANNELS.
Camille M. Hénault
, Casey L. Carswell, Sruthi
Murlidaran, JP Daniel Therien, Peter F. Juranka, Julian A. Surujballi,
Grace Brannigan, John E. Baenziger