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135

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

T

U

E

S

D

A

Y

2244-P

os

B

oard

B381

STEADY-STATE PREDICTIONS FROM A COMPACT

COOPERATIVE KINETIC MODEL OF CARDIAC SARCOMERE

DYNAMICS.

William C. Hunter

2245-P

os

B

oard

B382

SERINE 61 PHOSPHORYLATION RESCUES

CARDIOMYOPATHIC EFFECTS OF TROPOMYOSIN

MUTATION. Gerrie P. Farman, Marek Orzechowski, Stefan Fischer,

Lehman William,

Jeffrey R. Moore

2246-P

os

B

oard

B383

MOLECULAR DYNAMICS STUDIES ON PHOSPHORYLATED

AND UNPHOSPHORYLATED CARDIAC TROPONIN.

Andrew E. Messer

, Maria Papadaki, Steven B. Marston, Ian R. Gould

2247-P

os

B

oard

B384

BORROWING FROM THE PLATYPUS: PROLINE SUBSTITUTION

IN CARDIAC TROPONIN I.

Anthony D. Vetter

, Brian R. Thompson,

Evelyne H. Houang, Yuk Sham, Joseph M. Metzger

2248-P

os

B

oard

B385

A COARSE-GRAINED MODEL TO STUDY CALCIUM

ACTIVATION OF THE CARDIAC THIN FILAMENT.

Jing Zhang

,

Steven D. Schwartz

2249-P

os

B

oard

B386

AN EXPLICITLY SOLVATED FULL ATOMISTIC MODEL

OF THE CARDIAC THIN FILAMENT AND APPLICATION

ON THE CALCIUM BINDING AFFINITY EFFECTS FROM

FAMILIAL HYPERTROPHIC CARDIOMYOPATHY LINKED

MUTATIONS.

Michael R. Williams

, Sarah J. Lehman, Jil C. Tardiff,

Steven D. Schwartz

Microtubules, Structure Dynamics, and

Associated Proteins (Boards B387-B405)

2250-P

os

B

oard

B387

TRANSFORMATION OF TAXOL-STABILIZED MICROTUBULES

INTO INVERTED TUBULIN TUBULES TRIGGERED BY A

TUBULIN CONFORMATION SWITCH.

Chaeyeon Song

, Miguel A.

Ojeda-Lopez, Daniel J. Needleman, Avi Ginsburg, Phillip A. Kohl, Youli

Li, Herbert P. Miller, Leslie Wilson, Uri Raviv, Myung Chul Choi, Cyrus

R. Safinya

2251-P

os

B

oard

B388

SINGLE-MOLECULE FRET REVEALS AN EXTENDED

STRUCTURE OF TAU BOUND TO TUBULIN

HETERODIMERS.

Ana M. Melo

, Garrett Cobb, Juliana Coraor, Shana

Elbaum-Garfinkle, Elizabeth Rhoades

2252-P

os

B

oard

B389

STATISTICAL MECHANICS PROVIDES NOVEL INSIGHTS

INTO MICROTUBULE STABILITY AND MECHANISM OF

SHRINKAGE.

Ishutesh Jain

, Mandar M. Inamdar, Ranjith Padinhateeri

2253-P

os

B

oard

B390

MOLECULAR DYNAMICS STUDY OF THE EFFECT OF

POLYAMINE ON MICROTUBULE CONFORMATIONS.

Chola Regmi

, Shengfeng Cheng

2254-P

os

B

oard

B391

MOLECULAR BASIS FOR AGE-DEPENDENT MICROTUBULE

ACETYLATION.

Antonina Roll-Mecak

, Agnieszka Szyk, Alexandra

Deaconescu, Jeffrey Spector, Max Valenstein, Niko Grigorieff

2255-P

os

B

oard

B392

KATANIN ACTIVITY IS REGULATED BY COMMON CELLULAR

COMPONENTS.

Megan E. Bailey

, Jennifer L. Ross

2256-P

os

B

oard

B393

MOLECULAR BASIS FOR AGE-DEPENDENT ACETYLATION BY

TUBULIN ACETYLTRANSFERASE.

Jeffrey Spector

, Agnieszka Szyk,

Alexandra M. Deaconescu, Max Valenstein, Benjamin Goodman, Vasilisa

Kormendi, Nikolaus Grigorieff, Antonina Roll-Mecak

2257-P

os

B

oard

B394

international

travel awardee

MICROTUBULE ELECTRODYNAMICS ASSOCIATED WITH

VIBRATIONAL NORMAL MODES.

Michal Cifra

, Daniel Havelka,

Marco A. Deriu, Ondřej Kučera

2258-P

os

B

oard

B395

MICROTUBULE-DRIVEN CONFORMATIONAL CHANGES IN

PLATELET MORPHOGENESIS.

Wylie Stroberg

, Seth Lichter

2259-P

os

B

oard

B396

TRIM50 INTERACTS WITH MICROTUBULES TO FACILITATE

VESICLE TRAFFICKING IN GASTRIC PARIETAL CELLS.

Kristyn N. Gumpper

, Mingzhai Sun, Jiaqing Huang, Pei-Hui Lin,

Miyuki Nishi, Hiroshi Takeshima, Jianjie Ma

2260-P

os

B

oard

B397

GENERATION OF DIFFERENTIALLY MODIFIED

MICROTUBULES USING IN VITRO ENZYMATIC

APPROACHES.

Annapurna Vemu

2261-P

os

B

oard

B398

DYNAMICS OF MICROTUBULE NETWORKS WITH

ANTIPARALLEL CROSSLINKERS.

Kasimira T. Stanhope

, Jennifer L.

Ross

2262-P

os

B

oard

B399

KINETOCHORE DYNAMIC STRUCTURE AT SUPER-

RESOLUTION ACCURACY AND MECHANICAL STIFFNESS

REVEALED IN VITRO BY COMBINED TIRF AND OPTICAL

TWEEZERS.

Yi Deng

, Kwaku Opoku, Charles Asbury

2263-P

os

B

oard

B400

ASYMMETRIC FRICTION OF NON-MOTOR MAPS CAN LEAD

TO THEIR DIRECTIONAL MOTION IN ACTIVE MICROTUBULE

NETWORKS.

Scott Forth

, Kuo-Chiang Hsia, Yuta Shimamoto, Tarun

Kapoor

2264-P

os

B

oard

B401

THE DETERMINATION OF YOUNG’S MODULUS FOR

MICROTUBULES STABILIZED WITH TAXOL AND ANALYSIS

OF VIBRATIONAL MODES.

John Palmieri

, Camelia Prodan, Gordon

Thomas

2265-P

os

B

oard

B402

REGULATION OF TAU DYNAMICS BY PHOSPHORYLATION IN

THE SQUID GIANT AXON.

Miranda Redmond

, Gregory Hoeprich,

Meghan Pantalia, Gerardo Morfini, Christopher Berger

2266-P

os

B

oard

B403

GENERATION OF DIFFERENTIALLY MODIFIED

MICROTUBULES USING IN VITRO ENZYMATIC

APPROACHES. Annapurna Vemu,

Christopher P. Garnham

, Duck-

Yeon Lee, Antonina Roll-Mecak

2267-P

os

B

oard

B404

A COMPARISON OF THE CONFORMATIONAL CHANGES OF

TAU ISOFORMS IN THE TAU-TUBULIN COMPLEX.

Juliana Coraor

, Ana M. Melo, Garrett Cobb, Elizabeth Rhoades

2268-P

os

B

oard

B405

ANALYZING THE FREQUENCY OF THERMALLY

FLUCTUATING SEGMENTS OF MICROTUBULES.

Jennifer Rochette

, Camelia Prodan, Gordon Thomas