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133

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

T

U

E

S

D

A

Y

2196-P

os

B

oard

B333

MECHANISMS OF TREK-2 POTASSIUM CHANNEL

GATING.

Conor McClenaghan

, Elizabeth Carpenter, Tucker J. Stephen

2197-P

os

B

oard

B334

THE MOLECULAR BASIS FOR HEME MODULATION OF KATP

CHANNELS.

Mark Burton

, Sofia Kapetanaki, Noel Davies, John

Mitcheson, Ralf Schmid, Peter Moody, Emma Raven, Nina Storey

2198-P

os

B

oard

B335

NMR STRUCTURAL STUDIES OF THE BINDING OF

ACTIVATING MAMBA TOXIN TX7335 ON THE POTASSIUM

CHANNEL KCSA.

Jing Zhu

, Ulfat Shahzad, Sebastien F. Poget

2199-P

os

B

oard

B336

MECHANISM OF INHIBITION OF THE GLUA1 AMPA

RECEPTOR CHANNEL OPENING BY 2,3-BENZODIAZEPINE

COMPOUNDS.

AndrewWu

2200-P

os

B

oard

B337

SIMULTANEOUS MEASUREMENTS OF INTRACELLULAR [CA

2+

]I

AND [CAMP]I IN INTACT ISLETS TO STUDY THE MECHANISM

UNDERLYING DOPAMINERGIC INHIBITION OF INSULIN

SECRETION.

Alessandro Ustione

, David W. Piston

2201-P

os

B

oard

B338

DETERMINING THE DOPAMINERGIC FEEDBACK

PATHWAY IN PANCREATIC

β

-CELLS WITH FLUORESCENCE

FLUCTUATION SPECTROSCOPY.

Brittany Caldwell

, Alessandro

Ustione, David Piston

Other Channels (Boards B339-B366)

2202-P

os

B

oard

B339

STATISTICAL ANALYSIS OF MULTICHANNEL SIGNALS. Rishabh

Kumar, Prashant Srinivasa,

Horia I. Petrache

2203-P

os

B

oard

B340

NOVEL STEP DETECTION ALGORITHMS FOR

PHOTOBLEACHING ANALYSIS OF PROTEIN COMPLEXES

WITH MANY SUBUNITS.

Nathan C. Deffenbaugh

, Yalei Chen,

Charles T. Anderson, William O. Hancock

2204-P

os

B

oard

B341

SINGLE-FILE WATER PERMEATION THROUGH AQUAPORIN

CHANNELS.

Peter H. Nelson

2205-P

os

B

oard

B342

MAKING AN AQUAPORIN WATER-TIGHT: STRUCTURAL

BASIS OF SELECTIVITY IN PLANT NODULIN 26 INTRINSIC

PROTEINS.

Zachary G. Beamer

, Tian Li, Jerome Baudry, Daniel M.

Roberts

2206-P

os

B

oard

B343

MECHANISM OF PROTON TRANSPORT OF THE M2 PROTON

CHANNEL STUDIED BY CONSTANT PH MOLECULAR

DYNAMICS.

Wei Chen

, Jana K. Shen

2207-P

os

B

oard

B344

PROTON PERMEATION IN CI-HV1 VOLTAGE-GATED PROTON

CHANNELS OCCURS THROUGH A PROTON WIRE INVOLVING

RESIDUES D160 AND D222 AND IT IS MODULATED BY

N264.

Amaury Pupo

, David Baez-Nieto, Ester Otarola, Osvaldo

Yañez, Ariela Vergara-Jaque, Wendy Gonzalez, Karen Castillo, Gustavo

Contreras, H. Peter Larsson, Ramón Latorre, Carlos Gonzalez

2208-P

os

B

oard

B345

FREE ENERGY SIMULATIONS OF ION TRANSLOCATION

THROUGH VOLTAGE-GATED PROTON CHANNEL

HV1.

Kethika Kulleperuma

, Susan M. E. Smith, Thomas E. DeCoursey,

Regis Pomes

2209-P

os

B

oard

B346

INVESTIGATING THE POTENTIATION EFFECT OF 2-APB ON

CRAC CHANNELS.

Xiaolan Xu

, Sher Ali Syed, Tao Xu

2210-P

os

B

oard

B347

SLO2.X POTASSIUM CHANNELS ARE INVOLVED IN

THE REGULATION OF HEART MITOCHONDRIAL

FUNCTION.

Charles Owen Smith

2211-P

os

B

oard

B348

HUMAN ERYTHROCYTE MECHANO-ACTIVATED K

+

CHANNEL

A, A KINETIC STUDY OF INTRABURST ACTIVITY: EFFECT OF

CHLORPROMAZINE. Alejandro Mata,

Jesus G. Romero

2212-P

os

B

oard

B349

MECHANISMS UNDERLYING THE LOSS-OF-FUNCTIONAL

KIR6.1 KATP CHANNEL MUTATIONS IN SUDDEN INFANT

DEATH SYNDROME.

Bi-Hua Tan

, Blaise Z. Peterson, Ryan Li, Tianyu

Sun, Sinisa Dovat, Michael J. Ackerman, Chunhua Song

2213-P

os

B

oard

B350

STUDYING CLUSTERING OF KCSA CHANNELS USING SINGLE-

CHANNEL VOLTAGE-CLAMP FLUORESCENCE IMAGING.

Hugo McGuire

, Rikard Blunck

2214-P

os

B

oard

B351

CRYSTAL STRUCTURE OF FLUC, A MICROBIAL FLUORIDE

CHANNEL.

Randy Stockbridge

, Ludmila Kolmakova-Partensky, Akiko

Koide, Shohei Koide, Simon Newstead, Christopher Miller

2215-P

os

B

oard

B352

TWO-SIDED SIMULTANEOUS BLOCK OF A F- CHANNEL

(FLUC).

Daniel L. Turman

, Randy Stockbridge, Christopher Miller

2216-P

os

B

oard

B353

REGULATION OF CLC-3 CL-/H

+

TRANSPORT AND “GATING”

TRANSIENTS BY CHLORIDE PATHWAY RESIDUES AND

EXTERNAL PROTONS.

Jeffrey Rohrbough

, Fred S. Lamb, Hong-

Ngan Nguyen

2217-P

os

B

oard

B354

ENERGETICS AND MECHANISM OF PERMEATION ACROSS

FNT CHANNELS.

Kalina Atkovska

, Jochen Hub

2218-P

os

B

oard

B355

international

travel awardee

EXTRACELLULAR CHLORIDE REGULATES TMEM16A

GATING. Juan A. Contreras-Vite,

Silvia Cruz-Rangel

, Patricia Pérez-

Cornejo, H. Criss Hartzell, Jorge Arreola

2219-P

os

B

oard

B356

ACTIVATION OF ATP SECRETION VIA VOLUME-REGULATED

ANION CHANNELS BY SPHINGOSINE-1-PHOSPHATE IN RAW

MACROPHAGES. Philipp Burow, Manuela Klapperstück,

Fritz Markwardt

2220-P

os

B

oard

B357

POSITIONING OF THE FIRST EXTRACELLULAR LOOP OF

CFTR HAS SIGNIFICANT EFFECTS ON CFTR GATING.

Daniel T. Infield

, Guiying Cui, Christopher Kuang, Nael A. McCarty