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Biophysical Society 59
th
Annual Meeting, Baltimore, Maryland
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F
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10:45
am
–12:45
pm
, B
allroom
IV
Platform
Cytoskeletal Mechanics, Dynamics, Motility,
and Myosins
Co-Chairs
Michael Greenberg, University of Pennsylvania
Harvey Chin, Columbia University
118-P
lat
10:45
am
cpow
travel awardee
SITE-SPECIFIC CATION RELEASE DRIVES ACTIN FILAMENT
SEVERING BY VERTEBRATE COFILIN.
Hyeran Kang
, Michael
J. Bradley, Wenxiang Cao, Kaifeng Zhou, Elena E. Grintsevich, Alphée
Michelot, Emil Reisler, Charles V. Sindelar, Mark Hochstrasser, Enrique
M. De La Cruz
119-P
lat
11:00
am
HOW ACTIN INITIATES THE MOTOR ACTIVITY OF MYOSIN.
Virginie Ropars, Bin Zong, Paola Llinas, Tatiana Isabet, Lin Song, H. Lee
Sweeney,
Anne Houdusse
120-P
lat
11:15
am
STRUCTURAL BASIS FOR CALCIUM REGULATION OF THE
MOTOR FUNCTION OF MYOSIN-5A. Mei Shen, Sanduo Zheng,
Wen-Bo Zhang, Zekuan Lu,
Xiang-dong Li
121-P
lat
11:30
am
STRUCTURAL DETERMINANTS OF MYOSIN I
MECHANOSENSING: THE N TERMINAL REGION.
Michael J. Greenberg
, Tianming Lin, Henry Shuman, E. Michael Ostap
122-P
lat
11:45
am
MYOSIN 5 SIDE STEPS ALONG ACTIN. Jaime Ortega-Arroyo,
Joanna Andrecka, Yasuharu Takagi, James R. Sellers,
Philipp Kukura
123-P
lat
12:00
pm
PROBING LIPID VESICLE TRANSPORT IN 3D BY TEAMS OF
MYOSIN VA MOTORS AT SUSPENDED ACTIN INTERSECTIONS
IN VITRO.
Andrew T. Lombardo
, M. Yusuf Ali, Guy G. Kennedy,
Kathleen M. Trybus, David M. Warshaw
124-P
lat
12:15
pm
MEASUREMENTS AND SIMULATIONS OF THE FISSION YEAST
CYTOKINETIC RING TENSION DURING CONSTRICTION.
Harvey F. Chin
, Erdem Karatekin, Thomas D. Pollard, Ben
O’Shaughnessy
125-P
lat
12:30
pm
A MINIMAL SYSTEM TO ESTABLISH MICROTUBULE-BASED
CELL POLARITY
IN VITRO
.
Núria Taberner
, Pierre Recouvreux,
Sophie Roth, Marileen Dogterom
10:45
am
–12:45
pm
, R
oom
307/308
Platform
RNA Structure, Translation, and Splicing
Co-Chairs
Jeffrey Kieft, University of Colorado, Denver
Aaron Hoskins, University of Wisconsin-Madison
126-P
lat
10:45
am
BALANCED INTERACTIONS BETWEEN RIBOSOMAL
SUBUNITS ALLOW RAPID LARGE-SCALE ROTATION.
Lars V. Bock
, Christian Blau, Andrea C. Vaiana, Helmut Grubmüller
127-P
lat
11:00
am
REAL-TIME OBSERVATION OF DNA RECOGNITION BY
THE RNA-GUIDED ENDONUCLEASE CAS9 USING SINGLE-
MOLECULE FRET.
Digvijay Singh
, Samuel H. Sternberg, Jingyi Fei,
Jennifer A. Doudna, Taekjip Ha
128-P
lat
11:15
am
STRUCTURAL POLYMORPHISM OF CAG RNA REPEATS
INVESTIGATED BY SINGLE-MOLECULE MECHANICAL
UNFOLDING.
Pan T. Li
, William Stephenson
129-P
lat
11:30
am
HOW FLAVIVIRUSES USE A UNIQUE ‘SLIPKNOT-LIKE’
STRUCTURE TO MECHANICALLY CONFOUND A CELLULAR
EXONUCLEASE AND PRODUCE PATHOGENIC RNA. Erich G.
Chapman, David A. Costantino, Jennifer L. Rabe, Stephanie L. Moon, Jay
C. Nix, Jeffrey Wilusz,
Jeffrey S. Kieft
130-P
lat
11:45
am
MAPPING LONG NON-CODING RNA STRUCTURES WITH
FRAGMENTATION AND NEXT-GENERATION SEQUENCING.
Jeffrey Vieregg
, William Richter, Alex Ruthenburg
131-P
lat
12:00
pm
U2 SNRNA CONFORMATION IS REGULATED BY CUS2 TO
FACILITATE DEAD-BOX PROTEIN LOADING. U. Sandy Tretbar,
Aaron Hoskins
132-P
lat
12:15
pm
RNA FLEXIBILITY DEPENDS ON STRUCTURAL CONTEXT.
Julie Sutton
, Lois Pollack
133-P
lat
12:30
pm
SINGLE-MOLECULE STUDIES OF KISSING LOOP
INTERACTIONS IN GUANINE RIBOSWITCH.
Maumita Mandal
10:45
am
–12:45
pm
, R
oom
309/310
Platform
Membrane Pumps, Transporters, and
Exchangers I
Co-Chairs
Gregory Verdon, Imperial College London, United Kingdom
Joseph Mindell, NIH/NINDS
134-P
lat
10:45
am
STRUCTURE AND BIOCHEMICAL CHARACTERIZATION OF
THE MAMMALIAN FRUCTOSE TRANSPORTER GLUT5.
Gregory Verdon
, Hae Joo Kang, Saba Abdul-Hussein, Abdul Aziz
Qureshi, Michihiro Kasahara, So Iwata, Norimichi Nomura, David Drew
135-P
lat
11:00
am
THE CONFORMATIONAL DYNAMICS OF A SECONDARY
MULTIDRUG TRANSPORTER ARE MODULATED BY THE LIPID
BILAYER COMPOSITION.
Chloé Martens
136-P
lat
11:15
am
THERMODYNAMIC FEATURES OF IIAGLC INHIBITION OF
SUGAR SYMPORTERS.
Hariharan Parmeswaran
, Balasubramaniam
Dhandayuthapani, Alan Peterkofsky, Ronald H. Kaback, Lan Guan
137-P
lat
11:30
am
TRANSPORT COUPLING STOICHIOMETRY DETERMINATION
OF ELECTROGENIC SECONDARY TRANSPORTERS.
Gabriel A. Fitzgerald
, Christopher Mulligan, Joseph A. Mindell
138-P
lat
11:45
am
LIGAND-DEPENDENT CONFORMATIONAL CYCLE OF THE
NA+/HYDANTOIN TRANSPORTER MHP1.
Kelli Kazmier
, Shruti
Sharma, Shahidul M. Islam, Benoit Roux, Hassane S. Mchaourab
139-P
lat
12:00
pm
A KEY ROLE FOR TM5 IN THE NA
+
-COUPLED ALTERNATING-
ACCESS MECHANISM REVEALED BY COMPUTATIONAL
ANALYSIS OF THE MHST STRUCTURES. Zheng Li,
Sebastian Stolzenberg
, Matthias Quick, Lina Malinauskaite, Poul Nissen,
Harel Weinstein, Jonathan A. Javitch, Lei Shi