1712-1713 / 2063
•
Toxicity of initial treatment must be
considered, independently of blood cell
counts that may be misleading!
time
relative cell number
high dose/toxicity
peripheral cells
stem cells
stimulated
transit
proliferation
stem cells
time
relative cell number
low dose/toxicity
peripheral cells
stimulated
transit
proliferation
Earlier recovery of peripheral cell number does not reflect recovery of
stem cell population (
i.e.
restoration of radiation tolerance)