1720-1721 / 2063
Skin
•
Late radiation effects – mouse hind-limb
Two 10-fraction
courses separated by
6 months
Effect of re-irradiation
more pronounced
after more aggressive
initial treatment
Poorer retreatment
tolerance than for
early skin reactions
Brown & Probert Radiol 1975
Reirradiation dose per fraction (Gy)
3
4
5
6
7
Severity (arbitrary units)
0
1
2
3
4
5
6
7
hind limb deformation
treatment
alone
post 10
×
5 Gy
post 10
×
4 Gy