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Lung
•
Retreatment tolerance of the mouse lung
0
1
2
3
4
5
6
Retreatment-LD50 (Gy)
6
8
10
12
14
pneumonitis
post 6 Gy
treatment alone
post 8 Gy
post 10 Gy
Time after first treatment (months)
Terry Int J Radiat Oncol Biol Phys 1988
Initial dose <50% tolerance:
full recovery
, 2 months
Higher initial doses:
partial recovery
, 3 months
Only applies for pneumonitis
phase: retreatment tolerance
fibrosis might be poorer