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Lung

Retreatment tolerance of the mouse lung

0

1

2

3

4

5

6

Retreatment-LD50 (Gy)

6

8

10

12

14

pneumonitis

post 6 Gy

treatment alone

post 8 Gy

post 10 Gy

Time after first treatment (months)

Terry Int J Radiat Oncol Biol Phys 1988

Initial dose <50% tolerance:

full recovery

, 2 months

Higher initial doses:

partial recovery

, 3 months

Only applies for pneumonitis

phase: retreatment tolerance

fibrosis might be poorer