1714-1715 / 2063
Urinary bladder (mouse)
•
Original tolerance restored between 25-50
days
14
Time to reirradiation [days]
0
20
40
60
80
100 120
Retreatment ED50 [Gy]
0
5
10
15
20
25
30
initial RT: 5x5.3 Gy / 5 d
retreatment alone
Time after first treatment (days)
Retreatm t D
50
(Gy)
First treatment:
5
×
5.3 Gy over 1 week
Endpoint:
50% reduction in bladder
storage capacity at 1–3
weeks
post retreatment