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Summary.
The effect of acid therapy upon the acidity of the gastric contents
has been examined directly in
19
patients suffering from complete
achlorhydria. Ewald’s test meal
(35
grams crushed rusk and
250
grams tea vithout sugar or milk) was used and the effect of hydro
chloric acid, citric acid and betainhydrochloride investigated. Samples
were withdrawn from the stomach every 10 minutes and in each
sample the acidity was determined through titration with n/10 so
dium hydroxide, congo-red and phenolphthalein being used as indi
cators; the hydrogen ion concentration was determined with the
potentiometer.
,
The investigations showed that in the majority of the cases, the
effect of acid administered together with the food to patients with
achlorhydria is much less than would be expected theoretically
and from examinations in vitro. A remarkable lowering of the aci
dity takes place in the stomach, only relatively few of the samples
withdrawn giving a positive reaction to congo-red, and the acid
administered most often being neutralized before the stomach is
empty. It is considered possible that the lowering of the acidity is —
caused by neutralization with regurgitant duodenal juice, and that
this is especially pronounced because patients with achlorhydria
have a bad pyloric function.
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