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INFORMS Philadelphia – 2015

329

2 - Mining Association between Promotions and Transactions to

Find Optimum Time for Targeted Promotions

Hari Koduvely, Dr, Samsung, # 2870,Orion Building, Outer Ring

Road, Bangalore, K, 560037, India,

hari.koduvely@gmail.com,

Roshni Mohandas

In the usual Targeted Promotion scenario one optimizes the promotion content

tailored towards a consumer’s purchase interests to maximize response. However

time of targeting a promotion also equally important. In this paper we present a

new method, based on the temporal association patterns between promotion and

transaction events, to find the optimum time for targeted promotions. We validate

our method against existing approaches on a real retail data set and show

significantly better results.

3 - The Effect of Non-local Diversity in Dynamic Class Prediction

Senay Yasar Saglam, PhD Student, University of Iowa, 108

Pappajohn Business Building, S210, Iowa City, IA, 52242, United

States of America,

senayyasarsaglam@gmail.com

, Nick Street

Classifiers’ agreement in the region where a new data instance resides in has been

considered a major factor in dynamic ensembles. We hypothesize that in this

region the agreement among classifiers that are different is more important than

among the similar ones. In other words, high local accuracy and confidence, and

high diversity in other regions, is desirable. In this study, we check the validity of

this hypothesis and verify that diversity still plays a role in the dynamic class

prediction.

4 - Measuring Influence in Online Social Network Based on the

User-content Bipartite Graph

Zhiguo Zhu, Associate Prof., Dongbei University of Finance and

Economics, No. 217 JianShan St., Shahekou District, Dalian,

110625, China,

zhuzg0628@126.com

How to precisely identify and measure influence has been a hot research

direction. Differentiating from existing researches, we are devoted to combining

the status of users in the network and the contents generated from these users to

synthetically measure the influence diffusion. In this paper, we firstly proposed a

directed user-content bipartite graph model. Finally, the experiment results verify

our proposed model can discover most influential users and popular broads

effectively.

TC33

33-Room 410, Marriott

Appointment Scheduling in Healthcare

Sponsor: Health Applications

Sponsored Session

Chair: Armagan Bayram, Northwestern University, 2145 Sheridan

Road, Evanston, IL, 60201, United States of America,

abayram@northwestern.edu

1 - Ensuring Timely Access and Adequate Capacity for an

Endocrinology Clinic

Moses Chan, University of Michigan, 1205 Beal Avenue,

Ann Arbor, MI, United States of America,

mosesyhc@umich.edu

,

Amy Cohn, Amy Rothberg

The weight management program was designed to promote weight loss for

morbidly obese patients. Program participation is associated with reductions in

BMI and improvements in cardiovascular risk factors and quality of life. Providers

are booked weeks out, posing a challenge to schedule consecutive weekly visits.

Non-adherence to schedule undermines the effectiveness of the program. The

purpose of this study is to improve patient compliance with the program and to

increase program access.

2 - An Online Appointment Scheduling Model

Ali Kemal Dogru, Om PhD Student, University of Alabama, 315

Bidgood Hall, 361 Stadium Drive, Tuscaloosa, AL, 35487, United

States of America,

akdogru@crimson.ua.edu,

Sharif Melouk

Incorporating patient centered medical home (PCMH) principles, we develop an

online appointment scheduling system (OASS) for a primary care setting. We

propose a simulation optimization solution approach that uses two models

working in concert to provide high quality solutions (i.e., schedules) in short

time. We aim to minimize: 1) weighted cost of expected patient waiting time and

2) doctor idle time and overtime. Key Words: Online Appointment Scheduling,

Simulation Optimization, PCMH

3 - Managing Series Patients in a Healthcare Facility

Siyun Yu, STOR Department, UNC-Chapel Hill, B26 Hanes Hall,

Chapel Hill, NC, 27514, United States of America,

yusiyun@live.unc.edu,

Vidyadhar Kulkarni, Vinayak Deshpande

Series patients are scheduled for a series of appointments, such as patients in

physical therapy clinic, dialysis center, etc. To balance the demands from different

types of new as well as returning patients and the available appointment slots, we

develop stochastic models to determine the number of slots and the scheduling

policy that optimize performance. Heuristic polices are proposed which share the

same structural properties of the optimal policy and are more computationally

efficient.

4 - Managing Virtual Appointments in Chronic Care

Armagan Bayram, Northwestern University, 2145 Sheridan Road,

Evanston, IL, 60201, United States of America,

abayram@northwestern.edu

, Seyed Iravani, Sarang Deo,

Karen Smilowitz

Virtual visits can assist in managing chronic conditions by providing low cost

monitoring, treatment and education. Motivated by these benefits, we develop

capacity allocation models that decide which patients to schedule given limited

availability of both office and virtual visit slots. We model this problem using a

dynamic programming framework over a finite horizon, and perform analytical

and numerical analyses to identify policies for scheduling patients for different

medical interventions.

TC34

34-Room 411, Marriott

Optimal Cancer Therapy

Sponsor: Health Applications

Sponsored Session

Chair: Kevin Leder, Assistant Professor, University of Minnesota,

111 Church St, Minneapolis, MN, 55455, United States of America,

lede0024@umn.edu

1 - Nonstationary Spatiotemporally Integrated Fractionation

Ali Ajdari, University of Washington, Industrial and Systems

Engineering, Seattle, WA, 98195,

ali.adr86@gmail.com,

Archis Ghate

We consider the optimal fractionation problem where the fluence-maps are

allowed to change over treatment sessions. This results in a high-dimensional

nonconvex dynamic optimization problem. We present an approximate solution

method rooted in convex and dynamic programming.

2 - Treatment of Chronic Myeloid Leukemia with Multiple

Targeted Therapies

Qie He, University of Minnesota, 111 Church Street SE,

Minneapolis, MN, United States of America,

qhe@umn.edu,

Junfeng Zhu, Kevin Leder, Jasmine Foo

Recently several targeted therapies have been developed to treat Chronic Myeloid

Leukemia (CML). A significant problem is the development of resistance to

therapy in patients. Therapy combination can slow this development, but the

number of combinations is huge. We develop a model to find combinations that

are promising for clinical trials. The model captures cell evolution and toxicity

constraints. Our optimal combinations are predicted to significantly outperform

common clinical practice.

3 - Combined Therapy in Acute Lymphoblastic Leukemia

Kevin Leder, Assistant Professor, University of Minnesota, 111

Church St, Minneapolis, MN, 55455, United States of America,

lede0024@umn.edu

Acute lymphoblastic leukemia is a cancer of the blood system. While successful

treatment of the disease in juvenile patients is possible, it is difficult to treat in

adult patients. One treatment modality is the use of the targeted therapy nilotinib.

However, drug resistance is a serious issue. To avoid this drug resistance we

consider the combination of nilotinib and radiation. We develop a mathematical

model for this combined therapy and compare with experimental observations.

TC34