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86

Biophysical Society 59

th

Annual Meeting, Baltimore, Maryland

1293-P

os

B

oard

B244

education

travel awardee

UNRAVELING THE DUAL ROLE OF SURFACTANT PROTEIN A

AT ATOMISTIC DETAIL.

Boon Chong Goh

, Michael J. Rynkiewicz,

Francis X. McCormack, Barbara A. Seaton, Klaus Schulten

1294-P

os

B

oard

B245

IDENTIFYING THE CHOLINE-CATION TYROSINE-PI

INTERACTIONS OF AN AMPHITROPIC PROTEIN.

Tao He

, Hanif

M. Khan, Cedric Grauffel, Nathalie Reuter, Anne Gershenson, Mary F.

Roberts

1295-P

os

B

oard

B246

MEMBRANE INTERACTION OF AMYLOID-BETA PEPTIDE

INDUCES SPONTANEOUS MEMBRANE INVAGINATION. Sha

Jin, Jörg Nikolaus, Andreas Herrmann,

Jan Bieschke

1296-P

os

B

oard

B247

THE NOVEL INHIBITOR “ANLE145C” EFFICIENTLY INHIBITS

FIBRIL FORMATION OF ISLET AMYLOID POLYPEPTIDE (IAPP)

AND USES DISTINCTLY DIFFERENT MODES OF ACTION IN

THE ABSENCE AND PRESENCE OF MEMBRANES.

Manikam

Sadasivam Saravanan

, Sergey Ryazanov, Andrei Leonov, Janine Seeliger,

Roland Winter, Armin Giese, Christian Griesinger, J Antoinette Killian

1297-P

os

B

oard

B248

INFLUENCE OF SEQUENCE AND LIPID TYPE ON MEMBRANE

PERTURBATION BY HUMAN AND RAT AMYLOID

β

-PEPTIDE

(1-42).

Anne M. Brown

, David R. Bevan

Membrane Receptors and Signal

Transduction II (Boards B249-B269)

1298-P

os

B

oard

B249

EFFECT OF THANATOPHORIC DYSPLASIA TYPE I MUTATIONS

ON FIBROBLAST GROWTH FACTOR RECEPTOR 3

DIMERIZATION.

Nuala Del Piccolo

, Kalina Hristova

1299-P

os

B

oard

B250

DECODING THE ROLE OF RECEPTOR DIMERIZATION IN

PLEXIN-SEMAPHORIN SIGNALING.

AdamW. Smith

, Morgan

Marita, Xiaojun Shi, William D. Comar

1300-P

os

B

oard

B251

SYNTHETIC MANIPULATION OF PIP2 LEVELS AND PIP2-

ASSOCIATED CHEMOTACTIC SIGNALING DISSECTION IN

DICTYOSTELIUM.

Yuchuan Miao

, Takanari Inoue, Peter Devreotes

1301-P

os

B

oard

B252

CHARGE SHIELDING OF PIP2 BY CATIONS REGULATES

ENZYME ACTIVITY OF PHOSPHOLIPASE C.

Jong Bae Seo

, Seung-

Ryoung Jung, Weigang Huang, Qisheng Zhang, Duk-Su Koh

1302-P

os

B

oard

B253

SOLUBLE AND IMMOBILIZED VEGF INDUCE DISTINCT

PATTERNS OF VEGFR2 PHOSPHORYLATION MEDIATED BY

INTRACELLULAR TRAFFICKING.

Lindsay E W Clegg

, Feilim Mac

Gabhann

1303-P

os

B

oard

B254

MEASURING THE ENERGETICS OF EPHA3 DIMERIZATION IN

LIVE MAMMALIAN CELLS.

Qingqing Cao

, Deo Singh, Chris King,

Matt salotto, Kalina Hristova

1304-P

os

B

oard

B255

LOCAL BILAYER REORGANISATION BY THE JM REGIONS OF

ALL HUMAN RTKS: A MULTISCALE MOLECULAR DYNAMICS

STUDY.

George Hedger

, Mark S.P. Sansom, Heidi Koldsø

1305-P

os

B

oard

B256

THE DIPOLE POTENTIAL INFLUENCES THE CLUSTERING OF

ERBB PROTEINS.

Tamas Kovacs

, Agnes Szabo, Janos Szollosi, Peter

Nagy

1306-P

os

B

oard

B257

HOMO AND HETERO DIMERIZATION OF RECEPTOR

PROTEIN TYROSINE PHOSPHATASES.

Elizabeth Dembicer

,

Maxwell Watkins, Damien Thevenin

1307-P

os

B

oard

B258

IN VIVO THERMODYNAMICS OF RTKS IN THE CELL

MEMBRANE: QUANTITATIVE SPECTRAL FRET.

Christopher R. King

, Kalina Hristova

1308-P

os

B

oard

B259

COMPARISON OF EGFR DIMER STABILITIES IN THE

PRESENCE AND ABSENCE OF THE LIGAND EGF.

Matt Salotto

,

Deo R. Singh, Chris King, Pat Byrne, Daniel Leahy, Kalina Hristova

1309-P

os

B

oard

B260

LABEL-FREE CHARACTERIZATION OF A NOVEL EARLY-STAGE

DRUG DISCOVERY PLATFORM.

Edward Esposito

, Verna Frasca,

Kevin Mattison

1310-P

os

B

oard

B261

PATTERNED LIGAND SURFACES REVEAL F-ACTIN AND

INTEGRIN ORGANIZATION AT EGF AND IGE RECEPTOR

SIGNALING COMPLEXES.

Devin Wakefield

1311-P

os

B

oard

B262

THE ENERGETICS OF THE CHROMOPHORE REGENERATION

PATHWAY IN RHODOPSIN.

He Tian

, Thomas Sakmar, Thomas

Huber

1312-P

os

B

oard

B263

international

travel awardee

LIGHT-INDUCED SWITCHING OF HAMP DOMAIN

CONFORMATION AND DYNAMICS REVEALED BY TIME-

RESOLVED EPR SPECTROSCOPY.

Daniel Klose

, Natalia

Voskoboynikova, Philipp S. Orekhov, Ioan Orban-Glass, Christian

Rickert, Martin Engelhard, Johann P. Klare, Heinz-Juergen Steinhoff

1313-P

os

B

oard

B264

DYNAMIC LIGAND-PROTEIN INTERACTIONS ALTER

RHODOPSIN’S CONFORMATIONAL ENSEMBLE:

SIMULATIONS OF RHODOPSIN AND OPSIN.

Letty Salas

, Nick

Leioatts, Shairy Danial, Tod Romo, Alan Grossfield

1314-P

os

B

oard

B265

ATRAP (AT1R ASSOCIATED PROTEIN) ROLE ON ANGIOTENSIN

II-MEDIATED NHE3 ACTIVITY MODULATION.

Juliano Z. Polidoro

, Nancy A. Rebouças

1315-P

os

B

oard

B266

ENVIRONMENTAL FACTORS ALLOWING STEM CELLS FROM

SKELETAL MUSCLE TURNING INTO CARDIAC MUSCLE LIKE

SPONTANEOUS BEATING CELLS. Hikari Hayashida, Wataru

Yamasaki,

Takayuki Miyanishi

1316-P

os

B

oard

B267

ROLES OF PHOSPHODIESTERASES IN CYCLIC NUCLEOTIDE

CROSS-TALK IN CARDIAC MYOCYTES.

Claire Y. Zhao

, Joseph L.

Greenstein, Raimond L. Winslow

1317-P

os

B

oard

B268

REGULATION OF THE CARDIAC

β

-ADRENERGIC PATHWAY

VIA CAMP-CGMP COMPETITION.

Claire Y. Zhao

, Joseph L.

Greenstein, Raimond L. Winslow