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87
Biophysical Society 59
th
Annual Meeting, Baltimore, Maryland
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1318-P
os
B
oard
B269
INTRACELLULAR SIGNALING PATHWAY OF CARDIAC
APOPTOSIS IN THE PREDIABETIC HEART. Leandro Sommese,
Marilen Federico, Carolina Zanuzzi, Enrique L. Portiansky, John
Dedman, Marcia Kaetzel, Wehrens H. Xander, Alicia Mattiazzi,
Julieta Palomeque
Intracellular Calcium Channels and
Calcium Sparks and Waves I
(Boards B270-B288)
1319-P
os
B
oard
B270
DYSSYNCHRONOUS HEART FAILURE IS ASSOCIATED WITH
SPATIALLY HETEROGENEOUS SPARK DENSITY IN LEFT
VENTRICULAR CARDIOMYOCYTES.
Justin G. Lichter
, Hui Li,
Robin Moss, Thomas S. Seidel, John H. Bridge, Frank B. Sachse
1320-P
os
B
oard
B271
INFLUENCE OF RYR2 INHIBITION KINETICS ON CALCIUM
SPARKS AND WAVES IN A 3D MODEL OF A CARDIAC
CELL.
Derek R. Laver
, Mohammad S. Imtiaz
1321-P
os
B
oard
B272
EFFECTS OF TRIAD GEOMETRY AND RYR GATING SCHEME
ON SIMULATED SKELETAL MUSCLE SPARKS.
János Vincze
,
Beatrix Dienes, Péter Szentesi, László Csernoch, Derek R. Laver
1322-P
os
B
oard
B273
SUBCELLULAR CA CHANNEL DISTRIBUTION AND CA
ALTERNANS IN ATRIAL MYOCYTES.
Zhen Song
, Korogyi Adam,
Peter H. Backx, Zhilin Qu
1323-P
os
B
oard
B274
COMPLEX EARLY AND DELAYED AFTERDEPOLARIZATION
DYNAMICS CAUSED BY VOLTAGE-CALCIUM COUPLING IN
CARDIAC MYOCYTES.
Zhen Song
, Christopher Y. Ko, Michael
Nivala, James N. Weiss, Zhilin Qu
1324-P
os
B
oard
B275
STRUCTURAL AND FUNCTIONAL DEFECTS OF T-TUBULAR
SYSTEM AND THEIR IMPLICATIONS IN CALCIUM
RELEASE AND CONTRACTION IN A MOUSE MODEL OF
HYPERTROPHIC CARDIOMYOPATHY.
Claudia Crocini
, Cecilia
Ferrantini, Raffaele Coppini, Marina Scardigli, Erica Lazzeri, Claudio
Chicchi, Ping Yan, Leslie M. Loew, Jill Tardif, Chiara Tesi, Francesco
Vanzi, Elisabetta Cerbai, Francesco S. Pavone, Leonardo Sacconi
1325-P
os
B
oard
B276
SIMULTANEOUS DETECTION AND COLOCALIZATION OF
CALCIUM SPARKS AND RYANODINE RECEPTOR CLUSTERS
IN CARDIAC MYOCYTES. Alex Vallmitjana, Florian Hiess, S.R. Wayne
Chen, Leif Hove-Madsen,
Raul Benitez
1326-P
os
B
oard
B277
REDUCED CA FLUX VIA RYANODINE RECEPTOR CLUSTER
SIZE OR UNITARY CURRENT CAN BOTH PROMOTE LONG-
LASTING CA SPARKS.
Daisuke Sato
, Thomas R. Shannon, Donald M.
Bers
1327-P
os
B
oard
B278
EXPRESSION AND FUNCTION OF INOSITOL
1,4,5-TRISPHOSPHATE RECEPTORS IN THE HEART.
Martha Iveth Garcia
, Darren Boehning
1328-P
os
B
oard
B279
OPPOSITE CHANGES OF CA
2+
WAVE THRESHOLD AND
FRACTIONAL SR CA
2+
RELEASE DURING SERCA STIMULATION
IN CARDIOMYOCYTES.
Miguel Fernandez-Tenorio
, Ernst Niggli
1329-P
os
B
oard
B280
ELEVATED HOMOCYSTEINE LEVELS RESULT IN CARBONYL
FORMATION ON RYR2 AND ENHANCED SENSITIVITY
OF SARCOPLASMIC RETICULUM TO ACTIVATION BY
CALCIUM.
Laura J. Owen
, Robert M. Strongin, Jeffrey D. Singer,
Jonathan J. Abramson
1330-P
os
B
oard
B281
PHOSPHODIESTERASE INHIBITION LEADS TO ACTIVATION
OF EPAC AND STIMULATION OF CA
2+
RELEASE FROM BOTH
THE GOLGI APPARATUS AND THE SR. Hannah M. Kirton,
Zhaokang Yang,
Derek S. Steele
1331-P
os
B
oard
B282
CARDIAC ALTERNANS OCCURS THROUGH THE SYNERGY OF
VOLTAGE- AND CALCIUM-DEPENDENT MECHANISMS. Minh
Tuan Hoang-Trong, W Jonathan Lederer,
M Saleet Jafri
1332-P
os
B
oard
B283
DEVELOPMENT OF CA ALTERNANS IN ATRIAL
MYOCYTES IS MODULATED BY ACTION POTENTIAL
MORPHOLOGY.
Giedrius Kanaporis
, Lothar A. Blatter
1333-P
os
B
oard
B284
UROCORTIN 2 REGULATES SARCOPLASMIC RETICULUM
CALCIUM VIA PHOSPHORYLATION OF PHOSPHOLAMBAN
AND SERCA ACTIVATION AND PROTECTS AGAINST PRO-
ARRHYTHMIC ALTERNANS IN CARDIAC MYOCYTES FROM
NORMAL AND FAILING HEARTS.
Stefanie Walther
, Joshua N.
Edwards, Joshua T. Maxwell, Florentina Pluteanu, Susanne Renz, Burkert
Pieske, Lothar A. Blatter
1334-P
os
B
oard
B285
CALCIUM MEDIATED MECHANISM OF EARLY
AFTERDEPOLARIZATIONS IN LQT2 VENTRICULAR
MYOCYTES.
Colin M. Rees
, Dmitry Terentyev, Bum-Rak Choi, Gideon
Koren, Alain Karma
1335-P
os
B
oard
B286
MULTISCALE CONSEQUENCES OF SPONTANEOUS
CALCIUM RELEASE ON CARDIAC DELAYED
AFTERDEPOLARIZATIONS.
Christopher Y. Ko
, Zhen Song, Zhilin
Qu, James N. Weiss
1336-P
os
B
oard
B287
FRET-BASED RYR-SELECTIVE DETECTION REVEALS NO
SIGNIFICANT COMPETITION BETWEEN CAM AND S100A1
BINDING TO RYRS.
Robyn T. Rebbeck
, Florentin R. Nitu, David
Rohde, Patrick Most, Donald M. Bers, David D. Thomas, Razvan L.
Cornea
1337-P
os
B
oard
B288
CALMODULIN POTENTIATES RYR2 BLOCK AND CA WAVE
SUPPRESSION BY FLECAINIDE. Nieves Gomez-Hurtado, Ye W. Oo,
Derek Laver,
Bjorn C. Knollmann
Excitation-Contraction Coupling I
(Boards B289-B316)
1338-P
os
B
oard
B289
international
travel awardee
DOXORUBICIN ALTERS CARDIOMYOCYTE CALCIUM
REGULATION AND STIMULATES MITOCHONDRIAL
SUPEROXIDE FLASH PRODUCTION.
Nicole Beard
, Amy Hanna,
Lan Wei-LaPierre, Kevin Tylock, Hermia Willemse, Angela Dulhunty,
Robert Dirksen